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Principles of Anticancer Drug Development
  • Language: en
  • Pages: 673

Principles of Anticancer Drug Development

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
  • Language: en
  • Pages: 381

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH plat...

Les Manuscrits de Chrétien de Troyes
  • Language: en
  • Pages: 568

Les Manuscrits de Chrétien de Troyes

  • Type: Book
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  • Published: 1993
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  • Publisher: Rodopi

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Endobronchial Ultrasound and EBUS-Guided TBNA: Training Manual
  • Language: en
  • Pages: 252

Endobronchial Ultrasound and EBUS-Guided TBNA: Training Manual

  • Type: Book
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  • Published: 2022-04-27
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  • Publisher: Rake Press

This competency program addresses course organization, ultrasound physics, EBUS equipment and instrumentation, mediastinal exploration and staging, radiography- bronchoscopy correlations, image analysis, tumor markers, specimen handling, team dynamics and communication, and EBUS-related techniques. We provide validated assessment tools, simulation exercises, examples of practical approach case studies, and checklists to help assure patient and equipment safety.

Molecular and Cellular Therapeutics
  • Language: en
  • Pages: 331

Molecular and Cellular Therapeutics

Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.

OMICS
  • Language: en
  • Pages: 609

OMICS

  • Type: Book
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  • Published: 2016-04-19
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  • Publisher: CRC Press

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics researc

Clinical Trials Handbook
  • Language: en
  • Pages: 1247

Clinical Trials Handbook

Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every...

Multi-Drug Resistance in Cancer
  • Language: en
  • Pages: 228

Multi-Drug Resistance in Cancer

MULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are ...

New Trends in the Molecular and Biological Basis for Clinical Oncology
  • Language: en
  • Pages: 209

New Trends in the Molecular and Biological Basis for Clinical Oncology

Newly developed molecular target anticancer drugs have shown remarkable efficacy even in the treatment of intractable cancers such as hepatoma and renal cell carcinoma. As cancer research is becoming a multidisciplinary endeavor, close cooperation across the basic, translational, and clinical research fields holds the promise of further advances in cancer therapeutics. This book sets forth new strategies for development: cancer therapy targeting receptor tyrosine kinases with clinical utilization of new signaling regulations; interaction between cancer progression and extracellular environments such as inflammatory cytokines and the extracellular matrix; and investigation of biomarkers for personalized cancer therapy, with microarray analysis and pharmacogenomics technology. These and other findings from the latest investigations into cancer cell biology and therapeutics make this book an invaluable source for investigators in both the clinical and basic cancer research fields.

Cancer Biomarkers
  • Language: en
  • Pages: 970

Cancer Biomarkers

  • Type: Book
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  • Published: 2014-01-30
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  • Publisher: CRC Press

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer m