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Explainable Artificial Intelligence for Biomedical Applications
Since its first appearance, artificial intelligence has been ensuring revolutionary outcomes in the context of real-world problems. At this point, it has strong relations with biomedical and today’s intelligent systems compete with human capabilities in medical tasks. However, advanced use of artificial intelligence causes intelligent systems to be black-box. That situation is not good for building trustworthy intelligent systems in medical applications. For a remarkable amount of time, researchers have tried to solve the black-box issue by using modular additions, which have led to the rise of the term: interpretable artificial intelligence. As the literature matured (as a result of, in p...
Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine
This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are nec...
Myeloid Leukemia
The current book comprises a series of chapters from experts in the field of myeloid cell biology and myeloid leukemia pathogenesis. It is meant to provide reviews about current knowledge in the area of basic science of acute (AML) and chronic myeloid leukemia (CML) as well as original publications covering specific aspects of these important diseases. Covering the specifics of leukemia biology and pathogenesis by authors from different parts of the World, including America, Europe, Africa, and Asia, this book provides a colorful view on research activities in this field around the globe.
Human Interphase Chromosomes
This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species. Current biomedical sciences of post-genomic era refocus basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, related processes are a target of studies elucidating the role of interphase chromosome ...
Clinical Aspects of Inner Ear Deafness
The work on clinical aspects of inner ear deafness started out in 1983/1984 as a general review conceived by the Deutsche Gesellschaft fUr Hals-Nasen-Ohren-Heilkunde, Kopf-und Hals-Chirurgie (German Society for Oto-Rhino-Laryngology and Head and Neck Surgery) under the presidency of Professor Harald Feldmann, Munster. My task was to sift through the literature available at that time, to record the current status of knowledge, and if appropriate to describe existing new tendencies and potential developments. It was a conscious decision that the subject matter should extend to the entire field of inner ear deafness, though without reproducing too much of the detail given in the reviews already...
Genetic Translocations and Other Chromosome Aberrations
Chromosomal aberrations are disruptions in the normal chromosomal content of a cell, and are a major cause of genetic conditions in humans, such as Down syndrome. Some chromosome abnormalities do not cause disease in carriers, such as translocations, or chromosomal inversions, although they may lead to a higher chance of having a child with a chromosome disorder. Abnormal numbers of chromosomes or chromosome sets, aneuploidy, may be lethal or give rise to genetic disorders. Genetic counseling is offered for families that may carry a chromosome rearrangement. This book offers leading-edge research from around the world.
Trends in Birth Defects Research
Birth defects are defined as abnormalities of structure, function, or body metabolism that are present at birth. These abnormalities lead to mental or physical disabilities which can be fatal. There are over 4,000 different known birth defects ranging from minor to serious, and although many of them can be treated or cured, they are the leading cause of death in the first year of life. This book presents leading research in this field from around the world.
Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways
Since 1987, the most recent issues on tonsils and mucosal immunity have been discussed regularly at the 'International Symposiums on Tonsils and Mucosal Barriers of the Upper Airways' (ISTMB). This book is a summary of the topics presented during the 7th ISTMB covering both basic and clinical research on tonsils and upper airways. Presented are issues such as immunology and mucosal defense systems, bacteriology and virology, mucosal vaccine for upper airway infections, MALT, NALT and LALT, clinical manifests and pathogenesis of tonsil-related diseases such as IgA nephropathy, palmoplantal pustulosis, reactive arthritis diseases, and more related disorders. Further contributions reflect the association of tonsils with otitis media, allergic diseases in the upper airways, obstructive sleep apnea syndrome, and medical and surgical treatments for tonsil diseases. Otolaryngologists, pediatricians and immunologists who seek to unravel the mystery of the tonsil will find this volume of great assistance on their way to accomplish this task.
