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Diagnosis and Treatment of Aortic Diseases
This book is an up-to-date summary of all aspects of aortic disease, written by international experts in their fields, covering diagnostic concepts of all aortic diseases, the most modern therapeutic approaches in various aortic syndromes, the pathogenic origin and the most recent molecular and cellular findings that have revolutionized our present knowledge of aortic diseases. The reader will come to understand the aorta as a functional organ with a complex regulatory system rather than just a major arterial vessel, and will have a better understanding of the prognostic impact of various aortic syndromes, and of the most recent therapeutic concepts for chronic as well as acute aortic pathol...
The Natural and Modified History of Congenital Heart Disease
Exhaustive in its scope, this book provides a comprehensive study of the natural and modified history of congenital heart disease. Focusing particularly on the discussion of fetal and post-natal outcomes, the contributors seek to place developments in historical perspective. Virtually all surgical and catheter-based strategies to enhance outcomes of all forms of congenitally malformed heart are analysed, covering the morphology and genetic basis of each particular abnormality, and issues that were germane to evolving different therapeutic strategies. Using data from the records of the Toronto Hospital for Sick Children, contributors highlight the complications of the various forms of therapies and identifies particular risk factors for mortality and morbidity.
Contrast Echocardiography
Why a book on contrast echocardiography? Over the past dozen years enough experience has accumulated to warrant a more extensive treatment of this method. Furthermore, there are new developments that suggest increased clinical utility for contrast echocardiography in the future. This book aims to summarize the "state of the art" for those interested in echocardiography - presumably mainly cardiologists, but here and there those of a more technical bent will find useful information as well. We feel that a more basic understanding of microbubble dynamics is necessary to advance research for such applications as transmission through the lungs, videodensitometric quantitation of cardiac output, intracardiac shunts, etc. All of these topics are extensively dealt with. The reader will note that many of the clinical chapters are written by pediatric cardiologists. This is only natural, since shunt detection and analysis of flow relationships are relatively more important in congenital heart diseases, and cur rently represent the most important uses for contrast echo cardiography in day-to day practice.
Congenital Heart Disease
There are significant advances in the understanding of the molecular mechanisms of cardiac development and the etiology of congenital heart disease (CHD). However, these have not yet evolved to such a degree so as to be useful in preventing CHD at this time. Developments such as early detection of the neonates with serious heart disease and their rapid transport to tertiary care centers, availability of highly sensitive noninvasive diagnostic tools, advances in neonatal care and anesthesia, progress in transcatheter interventional procedures and extension of complicated surgical procedures to the neonate and infant have advanced to such a degree that almost all congenital cardiac defects can...
Paediatric Pathology
The increased provision of facilities for neonatal and paediatric care in the last 25 years has been accompanied only in part by appropriate developments in pathology. Specialist pathologists are many fewer than paediatric departments, and details of the advances in knowledge of the pathogenesis of diseases in childhood and of ways of investigating them are not uniformly available. In many institutions an individual with a special interest rather than a special training will be responsible for paediatric pathology and it is to this group of histopathologists that this text is addressed. For this reason it is not written as a comprehensive text and is not intended for use as a reference volum...
The Right Ventricle in Adults with Tetralogy of Fallot
Tetralogy of Fallot is the most common form of cyanotic congenital heart disease, and one of the first to be successfully repaired by congenital heart surgeons. Although “fixed”, patients born with tetralogy of Fallot cannot be considered “cured”. Improving survival and quality of life for this ever-increasing adult population will continue to challenge the current and future generations of cardiologists. Adult patients with tetralogy of Fallot should be seen by a cardiologist specializing in the care of adults with congenital heart disease, to be monitored for late complications. They need to be checked regularly for any subsequent complications or disturbances of heart rhythm. This monograph is intended as both an introduction to the subject and a timely, comprehensive review, and will be welcomed by adult cardiologists, pediatric cardiologists, internists, surgeons, obstetricians, and intensivists who wish to learn about the most recent discoveries and advances concerning tetralogy of Fallot in adults. It will also be of interest to advanced undergraduates wanting to learn more about the subject.
Calcific Aortic Valve Disease
Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.
Congenital Heart Diseases: The Broken Heart
This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and related animal models and pathways. Taken together these chapters, which were written by and for clinicians and researchers, provide an integrated and cutting-edge resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.
Tetraolgy of Fallot—A Cyanotic Congenital Heart Disease
Tetralogy of Fallot is one of the most common congenital heart diseases producing cyanosis in neonates, young infants, and children. Since first clinical description of the anatomical components characteristic of this congenital anomaly by Louis Arthur Etienne Fallot in 1888, this anomaly has been recognized well by clinicians as the cause of cyanosis in children. Since recognition of morphology of this anomaly and clinical symptoms and signs produced by this congenital anomaly were well understood, several treatments had evolved for management of this lesion to prevent morbidity and death from chronic cyanosis.
Diseases of the Arterial Wall
This text combines extensive coverage of normal structure and function of the arterial wall with detailed accounts of the changes that occur in disease. These data are presented in a comprehensive way not found elsewhere; they are essential for the proper understanding of arterial disease and for its investigation using modern methodology. Development and the factors controlling vessel form and structure are first discussed; and the normal cellular populations, functions and interactions are then considered. Particular topics, such as pulmonary hypertension, the effects of trauma on vessels, and diabetic vascular disease, are reviewed in detail. This book will be of interest to all involved in the management of vascular disease.
