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昆虫学报
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HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing
HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a memory-efficient data format for Hi-C contact maps. In addition, HiC-Pro can use phased genotype data to build allele-specific contact maps. We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro.
Nuclear Structure and Gene Expression
Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Healing from Hate
By the time Matthias was in seventh grade, he felt he’d better belong to some group, lest he be alone and vulnerable. The punks and anarchists were identifiable by their tattoos and hairstyles and music. But it was the skinheads who captured his imagination. They had great parties, and everyone seemed afraid of them. “They really represented what it meant to be a strong man,” he said. What draws young men into violent extremist groups? What are the ideologies that inspire them to join? And what are the emotional bonds forged that make it difficult to leave, even when they want to? Having conducted in-depth interviews with ex–white nationalists and neo-Nazis in the United States, as w...
Ottoman/Turkish Visions of the Nation, 1860-1950
Seeing the critical phase in the construction of a Turkish historical imagination between 1860 to 1950 disregarding the political disruptions, this book demonstrates how history and historical imagery had been instrumental in the nation-building process.
Denial of Violence
Denial of Violence seeks to decipher the roots of the denial by Turkish and Ottoman officials of acts of violence committed against Armenians. Based on a qualitative analysis of over 300 memoirs published in Turkey from 1789 to 2009, Fatma Müge Göçek analyzes denial as a multilayered process that starts with the advent of systematic modernity in the Ottoman Empire in 1789 and continues to this day in the Turkish Republic.
New Communication Approaches in the Digitalized World
The collection of essays reviews, explores and reports on the state of the digitalized world and a number of communication issues. It is a readable, non-technical publication which offers a comprehensive presentation of communication issues, trends, data, and likely future developments in the digitalized world.
Impact of Immigration and Xenophobia on Development in Africa
Human movement has an influence on the socio-economic dynamics of people, regions, and countries. The schisms between host and immigrants impact how host countries utilize immigrant skills and expertise to benefit their economies. However, immigrants are impacted by negative diplomatic relations between countries that limit the free movement of people and the welfare of immigrants. In association, this brings about social challenges such as Afrophobia, racism, xenophobia, hatred, and violence within these countries. While these challenges are deeply rooted across the world, Africa has its own unique challenges. Still struggling with massive underdevelopment, Africa needs to remove all the ne...
