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Directed Evolution
While the field of directed evolution is vast and varied, it comes from a simple principle: to apply the principles of biological evolution in the laboratory to generate useful molecules. This widely used technique has yielded blockbuster drugs, essential biological tools, and many more useful chemicals. Considering its impact, it’s unsurprising that the 2018 Chemistry Nobel Prize was awarded for the use of directed evolution of proteins. Directed Evolution is an excellent starting point for any scientist interested in directed evolution. This primer aims to provide readers with the foundational knowledge and vocabulary that enables them to tackle the literature and begin designing their p...
Expanding the Scope of the Enzymatic Synthesis of DNA for
DNA polymerases synthesize DNA, the essential biomolecule responsible for encoding the complex information necessary for life, with remarkable efficiency and fidelity. Chemists and biologists have exploited this extraordinary enzyme to develop a wide range of biotechnological tools, including but certainly not limited to PCR and Sanger sequencing. While these landmark applications continue to be relied upon to this day, they represent only a small fraction of the possible uses of these enzymes. Here, I detail my work to expand the scope of the enzymatic synthesis of DNA in two distinct fields. Chapters 2-5 detail efforts to identify replicable candidate unnatural base pairs to expand the gen...
Protein Engineering
Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the site-specific replacement of any amino acid in a protein with one of the other nineteen amino acids, it ushered in the new era of "Protein Engineering". The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins. The chapters included in this book reflect the rapid evolution of protein engineering and its many applications in basic research, biotechnology, material sciences and therapy. This book will provide the reader with an introduction to state-of the-art concepts and methods and will be of use to anyone interested in the study of proteins, in academia as well as in industry.
Modified Nucleic Acids
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Innovation and Experiential Learning in Academic Libraries
As technology advances and the skills required for the future workforce continue to change rapidly, academic libraries have begun to expand the definition of information literacy and the type of library services they provide to better prepare students for the constantly-developing world they will face upon graduation. More than teaching the newest technologies, information literacy is expanding to help students develop enduring skills such as critical thinking, creativity, problem solving, communication, teamwork, and more. Innovation and Experiential Learning in Academic Libraries: Meeting the Needs of 21st Century Students addresses the multitude of ways that academic librarians are collab...
Fake Papers
Fake Papers is a real-life escape story about a Holocaust survivor, who passes on survival lessons to her grandson, a documentary filmmaker working in war zones like Afghanistan.Letty is waiting to die. She is 90 years old and eaten by regret. She once told her story of survival to her grandson to help him through a tragedy when he was a child. Now in his thirties and a documentary filmmaker, he rushes to learn the details of her story before it disappears because in his grandma's story is a key to the unanswered questions that have haunted his life.When World War II began, seventeen-year-old Letty from a rigid Orthodox Jewish family in Belgium is trapped in a resort nestled in the French Py...
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