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The Circadian Clock
With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy...
Information- and Communication Theory in Molecular Biology
This edited monograph presents the collected interdisciplinary research results of the priority program “Information- and Communication Theory in Molecular Biology (InKoMBio, SPP 1395)”, funded by the German Research Foundation DFG, 2010 until 2016. The topical spectrum is very broad and comprises, but is not limited to, aspects such as microRNA as part of cell communication, information flow in mammalian signal transduction pathway, cell-cell communication, semiotic structures in biological systems, as well as application of methods from information theory in protein interaction analysis. The target audience primarily comprises research experts in the field of biological signal processing, but the book is also beneficial for graduate students alike.
Antibody Engineering
Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies.
Circadian Rhythms
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. Circadian Rhythms contains an extensive discussion of genetic and biochemical aspects of circadian rhythms. In this volume organisms such as neurospora, bacteria, drosophila, arabidopsis and mammals are covered. Included are methods in genetics, transcriptional and post-transcriptional regulation, tissue culture, and populations are discussed in detail.* One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences
Spektrum Psychologie - Selbstbild
Bewundern Sie andere manchmal für Leistungen, von denen Sie glauben, Sie selbst würden das niemals schaffen? Damit wären Sie gewiss nicht allein. Viele Menschen meinen, für bestimmte Dinge einfach kein Talent zu haben, sei es Mathe oder Musik, Sport oder Smalltalk. Kein Problem, solange man mit sich im Reinen ist. Doch verbauen wir uns damit womöglich etwas? Ein »statisches Selbstbild« stehe uns im Wege, schreibt die französische Psychologin Audrey Ginisty. Wie man das starre alte Selbst hinter sich lassen kann, schildert sie in der Titelgeschichte ab S. 18. Ihre Tipps: klein anfangen, sich Fehler erlauben und Erfolge nicht nur am Ergebnis messen. Vielleicht wollten Sie schon immer l...
Molecular Clocks and Light Signalling
The ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. The primary feature of these biological clocks is their ability to entrain to environmental stimuli. The dominant stimulus comes from environmental light cues, which requires the existence of photopigments sensitive to light. The exact identity of the molecules involved in circadian photoreception has remained elusive. The classical view of the circadian system is of diverse physiological rhythms regulated by a centralized clock structure. This book presents evidence that challenges this view. Experiments in both vertebrate and invertebrate systems demonstr...
Rigged
Rigged exposes a cover-up at the highest level on both sides of the Atlantic, upending the official story of the biggest scandal since the global financial crisis. It picks up where The Big Short leaves off, as the dark clouds of the financial crisis gather. Banks' health is judged by an interest rate called Libor (the London Interbank Offered Rate). The higher the Libor, the worse off the bank; too high and it's goodnight Vienna. Libor is heading skywards. To save themselves from collapse, nationalisation and loss of bonuses, banks instruct traders to manipulate Libor down – a criminal practice known as lowballing. Outraged, traders turn whistleblowers, alerting the authorities. As Rigged...
Transients and Bifurcations of the Mammalian Circadian System
Many organisms have an endogenous oscillatory system that controls their daily rhythms in physiology, metabolism and behaviour. In mammals, these oscillations are found in almost every cell and are orchestrated by a tiny brain area: the suprachiasmatic nucleus (SCN). This central pacemaker contains thousands of heterogeneous neurons that oscillate in a synchronized fashion and generate a robust about-a-day pace for the body. One of the fundamental properties of the SCN is to keep its internal period in synchrony with the external 24 hour environmental cycle, i.e., to entrain to the external recurring environment. Many properties of this complex network of coupled entrainable oscillators are poorly understood and the present work deals with some of these open questions.
Praxishandbuch Chronomedizin. Gesundheit und Biologische Rhythmen
Informieren Sie sich wissenschaftlich fundiert und praxisnah über die Zusammenhänge von biologischen Rhythmen und Gesundheit. Das Buch bietet Ihnen: - Kenntnisse über die biologischen Rhythmen unseres Organismus - Empfehlungen präventiver Maßnahmen zur Förderung der circadianen Gesundheit bei Kindern, Jugendlichen und Erwachsenen - Wissen über die Bedeutung der Chronomedizin für die Therapie von Schlaf-Wach-Störungen und den Stellenwert der Chronomedizin für personalisierte Behandlungen häufig auftretender Erkrankungen - Online abrufbar erhalten Sie: Empfehlungen für einen intakten Schlaf-Wach-Rhythmus bei Erwachsenen / Tipps für einen erholsamen Kinderschlaf / Muster eines SchlafprotokollsDas Buch eignet sich für: - Fachärzt*innen Innere Medizin - Fachärzt*innen Allgemeinmedizin - Fachärzt*innen Psychosomatische Medizin - Psychotherapeut*innen - Schlafmediziner*innen
Gehirn&Geist 10/22 - Wie die Welt im Kopf entsteht
Demenz ist heimtückisch. Langsam raubt sie Betroffenen ihre persönlichsten Schätze: die Erinnerungen an ihr eigenes Leben und an ihre Liebsten. Mehr als 50 Millionen Men¬schen weltweit leiden unter dem fortschreitenden kognitiven Abbau, bei einem Großteil von ihnen ist die Ursache Morbus Alzheimer. Gleich zwei Artikel in dieser Ausgabe widmen sich der neurodegenerativen Erkrankung. Ab S. 48 beleuchtet Alison Abbott, wieso experimentelle Alzheimermedikamente in Studien bisher schlechter als erhofft abschnitten. Die Ursache liegt womöglich im Timing. Denn sobald ernste Schäden im Hirn entstanden sind, ist es zu spät, um ihre Folgen abzubremsen. Weitere Untersuchungen sollen nun zeigen,...
