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This book targets computer scientists and engineers who are familiar with concepts in classical computer systems but are curious to learn the general architecture of quantum computing systems. It gives a concise presentation of this new paradigm of computing from a computer systems' point of view without assuming any background in quantum mechanics. As such, it is divided into two parts. The first part of the book provides a gentle overview on the fundamental principles of the quantum theory and their implications for computing. The second part is devoted to state-of-the-art research in designing practical quantum programs, building a scalable software systems stack, and controlling quantum hardware components. Most chapters end with a summary and an outlook for future directions. This book celebrates the remarkable progress that scientists across disciplines have made in the past decades and reveals what roles computer scientists and engineers can play to enable practical-scale quantum computing.
Digital violence continues to increase, especially during times of crisis. Racism, bullying, ageism, sexism, child pornography, cybercrime, and digital tracking raise critical social and digital security issues that have lasting effects. Digital violence can cause children to be dragged into crime, create social isolation for the elderly, generate inter-communal conflicts, and increase cyber warfare. A closer study of digital violence and its effects is necessary to develop lasting solutions. The Handbook of Research on Digital Violence and Discrimination Studies introduces the current best practices, laboratory methods, policies, and protocols surrounding international digital violence and discrimination. Covering a range of topics such as abuse and harassment, this major reference work is ideal for researchers, academicians, policymakers, practitioners, professionals, instructors, and students.
This review of recent developments in our understanding of the role of microbes in sustainable agriculture and biotechnology covers a research area with enormous untapped potential. Chemical fertilizers, pesticides, herbicides and other agricultural inputs derived from fossil fuels have increased agricultural production, yet growing awareness and concern over their adverse effects on soil productivity and environmental quality cannot be ignored. The high cost of these products, the difficulties of meeting demand for them, and their harmful environmental legacy have encouraged scientists to develop alternative strategies to raise productivity, with microbes playing a central role in these eff...
In 2002, sixty international specialists met to discuss problems of high P-unavailability as a soil nutrient for crops, and the hazards of increased phosphate input to aquatic habitats from industrial and mining activities, sewage disposal, detergents, and other sources. Among the presentations were updated solutions to enhance P-uptake by plants, bioremediation potential in the rehabilitation of ecosystems, taxonomic characterization interactions with mycorrizae, the physiological and molecular basis of PSM, and more.
"Much has been written about the famous conflicts and battlegrounds of the East during the American Revolution. Perhaps less familiar, but equally important and exciting, was the war on the western frontier, where Ohio Valley settlers fought for the land they had claimed -- and for their very lives. George Rogers Clark stepped forward to organize the local militias into a united front that would defend the western frontier from Indian attacks. Clark was one of the few people who saw the importance of the West in the war effort as a whole, and he persuaded Virginia's government to lend support to his efforts. As a result Clark was able to cross the Ohio, saving that part of the frontier from further raids. Lowell Harrison captures the excitement of this vital part of American history while giving a complete view of George Rogers Clark's significant achievements. Lowell H. Harrison, is a professor emeritus of history at Western Kentucky University and is the author or co-author of numerous books, including Lincoln of Kentucky, A New History of Kentucky, and Kentucky's Governors."
Summary: The focus of this book is on how the U.S. FDA will approve biosimilar drugs, as learned from recent approvals by the FDA. Understanding the limitations of the statutory limits and non-inferiority testing are presented as tools to obviate patient trials and minimize testing of immunogenicity. An in-depth scientific, mathematical and statistical view of the tools required to establish biosimilarity of biological drugs of different complexity -- a must for every developer of biosimilars. Features: First comprehensive analysis based on new guidelines and approval packages of several biosimilars Presents the first approach to challenge FDA in reducing or eliminating any testing in patients. Provides a comprehensive understanding of the U.S. statutory requirements vis-a-vis the regulatory guidelines Provides model CQA and Analytical Similarity testing protocols for cytokines and monoclonal antibodies Allow creation of a fast-to-market pathway to develop biosimilars
The aims and scope of this atlas include a complete review of the embryology of the normal heart, the normal cardiac anatomy along with a complete discussion of the terms and definitions used to identify and clarify both normal and abnormal anatomy. In addition, techniques of cardiac CT angiography as it pertains to imaging congenital abnormalities are discussed including radiation concepts and radiation saving techniques. The bulk of this book then goes on to completely review the field of adult congenital heart disease using text and more importantly a multitude of pictorial examples (in color and grey scale) to demonstrate the abnormalities. Drawings accompany each picture to better expla...
Proceedings of the NATO Advanced Study Institute on the Cosmological Background Radiation, Strasbourg, France, May 27-June 7, 1996
The earth’s biodiversity is a degree of ecosystem health which is vital to ecology and environmental sustainability. The microbial world is the largest unexplored reservoir. The agro-ecosystem enriched with rhizosphere implicit abundant and species-rich component of microbial diversity. Its global exploration designs a worldwide framework for agricultural sustainability adjoining benefits in its conservation. Agricultural sustainability requires a major share from ecosystem management which is better paid by microbial diversity and conservation. Diversity of bacteria influences plant productivity providing nutrient convenience from soil instead altering per se community and diversity in th...