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Las Enfermedades Raras (ER) son un grupo heterogéneo de patologías que se caracterizan por su baja prevalencia. Además presentan una elevada morbimortalidad, un carácter, generalmente, crónico y progresivo que origina invalidez y afectación de la calidad de vida. Este trabajo plasma los contenidos que se han desarrollado en plataformas online de fácil acceso para familias/afectados por enfermedades raras. Este acceso permite que estas personas puedan trabajar en mejorar su calidad de vida en el ámbito de la salud, psicológico y social. Lo que les ayudaría a manejar la situación tan compleja a la que se enfrentan.
This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the pr...
In Paper Cadavers, an inside account of the astonishing discovery and rescue of Guatemala's secret police archives, Kirsten Weld probes the politics of memory, the wages of the Cold War, and the stakes of historical knowledge production. After Guatemala's bloody thirty-six years of civil war (1960–1996), silence and impunity reigned. That is, until 2005, when human rights investigators stumbled on the archives of the country's National Police, which, at 75 million pages, proved to be the largest trove of secret state records ever found in Latin America. The unearthing of the archives renewed fierce debates about history, memory, and justice. In Paper Cadavers, Weld explores Guatemala's struggles to manage this avalanche of evidence of past war crimes, providing a firsthand look at how postwar justice activists worked to reconfigure terror archives into implements of social change. Tracing the history of the police files as they were transformed from weapons of counterinsurgency into tools for post-conflict reckoning, Weld sheds light on the country's fraught transition from war to an uneasy peace, reflecting on how societies forget and remember political violence.
This book contains case histories intended to show how societies and landscapes interact. The range of interest stretches from the small groups of the earliest Neolithic, through Bronze and Iron Age civilizations, to modern nation states. The coexistence is, of its very nature reciprocal, resulting in changes in both society and landscape. In some instances the adaptations may be judged successful in terms of human needs, but failure is common and even the successful cases are ephemeral when judged in the light of history. Comparisons and contrasts between the various cases can be made at various scales from global through inter-regional, to regional and smaller scales. At the global scale, ...
Deficits in social cognition and metacognition in schizophrenics makes it difficult for them to understand the speech, facial expressions and hence emotion and intention of others, as well as allowing little insight into their own mental state. These deficits are associated with poor social skills, fewer social relationships, and are predictive of poorer performance in a work setting. Social Cognition and Metacognition in Schizophrenia reviews recent research advances focusing on the precise nature of these deficits, when and how they manifest themselves, what their effect is on the course of schizophrenia, and how each can be treated. These deficits may themselves be why schizophrenia is so difficult to resolve; by focusing on the deficits, recovery may be quicker and long lasting. This book discusses such deficits in early onset, first episode, and prolonged schizophrenia; how the deficits relate to each other and to other forms of psychopathology; how the deficits affect social, psychological, and vocational functioning; and how best to treat the deficits in either individual or group settings.