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Applied Biclustering Methods for Big and High-Dimensional Data Using R
Proven Methods for Big Data Analysis As big data has become standard in many application areas, challenges have arisen related to methodology and software development, including how to discover meaningful patterns in the vast amounts of data. Addressing these problems, Applied Biclustering Methods for Big and High-Dimensional Data Using R shows how to apply biclustering methods to find local patterns in a big data matrix. The book presents an overview of data analysis using biclustering methods from a practical point of view. Real case studies in drug discovery, genetics, marketing research, biology, toxicity, and sports illustrate the use of several biclustering methods. References to technical details of the methods are provided for readers who wish to investigate the full theoretical background. All the methods are accompanied with R examples that show how to conduct the analyses. The examples, software, and other materials are available on a supplementary website.
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R
This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restr...
Minimally Invasive Cardiac Surgery
Minimally invasive cardiac surgery(MICS) is an integral component of every future cardiac surgeon’s training. There continues to be a growing global demand towards less invasive surgical techniques. Both cardiologist and cardiac surgeon form "heart teams" to provide patients with novel, minimally invasive procedures, with all their benefits. Less invasive techniques are often complex and require special knowhow and skills. This book offers an innovative approach to learning, utilizing QR code technology, which refers the reader to essential audio-visual material, which, along with the didactic text, focuses on practical aspects of minimally invasive cardiac surgery. In modern Heart Teams, ...
Health in Hard Times
Available Open Access under CC-BY-NC licence. How has austerity impacted on health and wellbeing in the UK? Health in Hard Times explores its repercussions for social inequalities in health. The result of five years of research, the book draws on a case study of Stockton-on-Tees in the north-east of England, home to some of the starkest health divides. By placing individual and local experiences in the context of national budget cuts and welfare reforms, it provides a holistic perspective on countrywide inequalities. Edited by a leading expert, this is an important book for anyone seeking to understand one of today’s most significant determinants of health.
Cash Not Care
Mo Stewart is a former healthcare professional, a disabled female veteran and an independent researcher. This book is the culmination of six years of self-funded research and the evidence exposes the influence of corporate America, since 1992, with the future welfare reforms of the UK. The impact of the enforced austerity measures of the UK government is identified, as they negatively affect the welfare and the survival of the chronically sick and disabled population in receipt of welfare benefits when unfit to work. The research has informed welfare reform debates in the House of Lords and the House of Commons since 2011 and contributed to the evidence used by the United Nations to investigate the UK government for breaches of the Human Rights of sick and disabled people. Endorsed by the disabled community and by academics, the research has identified the adoption of lethal social policies, copied from American social security policies, and linked to the death of thousands of the most vulnerable of all, as the UK welfare state is systematically demolished as all planned over thirty years ago by a previous Conservative government.
Methods in Comparative Effectiveness Research
Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will aid patients, clinicians, purchasers, and health policy makers in making informed decisions at both the individual and population levels. CER encompasses a very broad range of types of studies—experimental, observational, prospective, retrospective, and research synthesis. This volume covers the main areas of quantitative methodology for the design and analysis of CER studies. The volume has four major sections—causal inference; clinical trials; research synthesis; and specialized topics. The audience includes CER methodologists, quantitative-trained researchers interested in CER, and graduate students in statistics, epidemiology, and health services and outcomes research. The book assumes a masters-level course in regression analysis and familiarity with clinical research.
Statistical Topics in Health Economics and Outcomes Research
With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to request for HEOR evidence, in addition to data from clinical trials, to inform decisions about patient access to new treatment options. While there is a great deal of literature on HEOR, there is a need for a volume that presents a coherent and unified review of the major issues that arise in application, especially from a statistical perspective. Statistical Topics in Health Economics and Outcomes Re...
Applied Surrogate Endpoint Evaluation Methods with SAS and R
An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.
Cluster Randomised Trials
Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomisation, with special attention given to evaluating the effects of interventions against infectious diseases. Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. In the time since the publication of the first edition, the use of cluster randomised trials (CRTs) has increased substantially, which is reflected in the updates to this edition. There are greatly expanded sections on random...
Statistical Methods for Healthcare Performance Monitoring
Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statist...
