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A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intelle
This special issue of the Advances in Experimental Medicine and Biology presents much of the research described at the recent 2nd International Tissue Engineering Conference held in Crete in May 2005. The conference brought together over 150 researchers from around the world to examine the emerging and most advanced aspects of their particular field. The chapters reflect a diverse group of authors, including both clinicians and academicians.
Given the strong current attention of orthopaedic, biomechanical, and biomedical engineering research on translational capabilities for the diagnosis, prevention, and treatment of clinical disease states, the need for reviews of the state-of-art and current needs in orthopaedics is very timely. Orthopaedic Biomechanics provides an in-depth review of the current knowledge of orthopaedic biomechanics across all tissues in the musculoskeletal system, at all size scales, and with direct relevance to engineering and clinical applications. Discussing the relationship between mechanical loading, function, and biological performance, it first reviews basic structure-function relationships for most m...
Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.
Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral ...
Applications of Unsaturated Polyester Resins: Synthesis, Modifications, and Preparation Methods takes a practical approach to unsaturated polyester-based materials and their preparation for implementation in a range of innovative areas. Sections introduce the background of polyester and the fundamentals of unsaturated polyester resins (UPRs), including chemistry, additives, curing, and processing methods. Hydrolytic stability and structure-property relationships are also discussed in detail, along with coverage of modification strategies for UPR and the development of bio-composites incorporating natural fiber with unsaturated polyester. Subsequent chapters focus on the preparation of UPR fo...
This book provides an overview of the composition of polymeric and ceramic bone cements. It also discusses complex, biomimetic structures based on biomaterials, such as cells and bioactive molecules, which more closely resemble natural bone The first chapter describes the main concepts of the cementation process and the parameters affecting it, while the second chapter focuses on the composition and structure of candidate biomaterials. Lastly, the third and fourth chapters present recent research aimed at improving the ability of naked biomaterials to enhance bone healing by adding cells and bioactive agents.
This book acts as a self-contained resource for understanding the current technological advancement of biomaterials towards tissue engineering applications. It covers impact of biomaterials at different length scales such as macro/micro/nano/ level and offers extensive discussion on cell-biomaterial interactions with illustrative examples. This resource offer a multi-disciplinary approach for the adaptability of integrated biomaterials in tissue repair and reconstruction.
Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering covers core elements of scaffold design, from properties and characterization of polymeric scaffolds to fabrication techniques and the structure-property relationship. Particular attention is given to the cell-scaffold interaction at the molecular level, helping the reader understand and adapt scaffold design to improve biocompatibility and function. The book goes on to discuss a range of tissue engineering applications for polymeric scaffolds, including bone, nerve, cardiac and fibroblast tissue engineering. Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering is an important, interdisciplinary work of relevance to materials scientists, polymer scientists, biomedical engineers and those working regenerative medicine. - Helps the reader determine the most appropriate polymer for scaffold design by characterization, properties and structure-property relationship - Discusses material-cell interactions at the molecular level, aiding in determining suitability - Covers core elements of scaffold design, including fabrication techniques
Biomaterials work in contact with living matter and this gives a number of specific requirements for their surface properties, such as bioinertness or bioactivity, antibiofouling, and so on. Surface engineering based on physical, chemical, physical-chemical, biochemical or biological principles is important for the preparation of biomaterials with the desired biocontact properties. This book helps the reader gain the knowledge to enable them to work in such a rapidly developing area, with a comprehensive list of references given for each chapter. Strategies for tailoring the biological response through the creation of biomaterial surfaces resistant to fouling are discussed. Methods of elicit...