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Genetic Disorders Among Arab Populations
Arab populations have their “own” genetic disorders, both universal and particular. Genetic diversity within these source populations, along with the fact that the rates of inbreeding are often high and family sizes are often large, constitute conditions that facilitate the emergence and detection of phenotypes explained notably by autosomal recessive inheritance; in which case, the use of homozygosity gene mapping can facilitate the discovery of the corresponding genes. The present book includes 5 parts dealing with various aspects that relate to the genetic structure of Arabs and minorities within the Arab world as well as genetic disorders prevalent in this part of the world. It inclu...
Disability in the Ottoman Arab World, 1500-1800
This book is the first on the history of both physical and mental disabilities in the Middle East and North Africa during Ottoman rule.
Modern Polygamy in the United States
Few people realize that polygamy continues to exist in the United States. Thus, world-wide attention focused on the State of Texas in 2008 as agents surrounded the compound of The Fundamentalist Church of Jesus Christ of Latter-day Saints (FLDS) and took custody of more than 400 children. Several members of this schismatic religious group, whose women adorned themselves in "prairie dresses," admitted to practicing polygamy. The state justified the raid on charges that underage marriage was being forced on young women. A year later, however, all but one of the children had been returned to their parents and only ten men were charged with crimes, some barely related to the original charges. Th...
Objective Anaesthesia Review
The third edition of Objective Anaesthesia Review has been fully updated to help postgraduates in their exam preparation. Presented in an easy to follow, question and answer format, this textbook covers a range of topics in anaesthesia. Divided into two sections, the first part discusses numerous diseases and disorders, and the second describes anaesthesia equipment. Many chapters in this new edition have been revised and new chapters have been added including ‘Acute Postoperative Pain’ in the first section and ‘Videolaryngoscopes’ in the second section. Key points Fully updated, third edition helping anaesthesia trainees prepare for examinations Easy to follow, question and answer format, covering many clinical cases and anaesthesia equipment Includes new chapters and 265 images and illustrations Previous edition published in 2012
Congenital Anomalies of the Ear, Nose, and Throat
The modern assessment, understanding, management, and prevention of congenital anomalies of the ear, nose, and throat require a multi-disciplinary approach. This book provides a complete coverage of the subject in a precise manner, bridging the gaps between the disciplines of genetics, otolaryngology, plastic surgery, and pediatrics. It is divided into nine sections. The first includes general chapters on medical genetics and dysmorphology, physical measurement of the head and face, epidemiology, human teratogenic effects, and prenatal diagnosis. These are followed by sections on the ear, nose and sinuses, mouth, palate, pharynx, craniofacial region, neck and upper aerodigestive tract. In ea...
The Oxford Handbook of Disability History
This Handbook brings together twenty-nine authors from around the world, each expert in a different area within the history of disability. This collection of new and original essays forms a benchmark in a field of historical inquiry that has been growing and maturing over the last thirty years. It is the first book to gather critical essays that incorporate studies from South and East Asia, eastern and western Europe, Australia, North America, and the Arab world. This Handbook is unique among other disability history texts in that it engages simultaneously in methodological and historiographic debates and in a further articulation and analysis of the lived experiences of disabled people.
Transcription Factors and Human Disease
Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that pa...
Pharmacogenetics
Genes are important modifiers of human response to drugs, hormones, and toxins. Patients and healthy individuals alike display significant differences in response and suffer adverse effects as a result of exposure to many therapeutic agents as well as occupational chemicals. This introductory text brings together laboratory methods and epidemiologic studies for defining the role of heredity in human drug response. This book will benefit graduate students in pharmacology, genetics, epidemiology, nursing, and public health, and will serve as a handy reference for pharmacists, epidemiologists, and physicians responsible for the delivery and administration of drugs.
Inborn Errors of Development
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
