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New Research on Neurofilament Proteins
Neurofilaments serve as a necessity in brain sensory communications. They are important structural and cellular transportation proteins found in both afferent and efferent auditory neurons. The peripheral processes of auditory neurons innervate sensory hair cells within the cochlea and a loss of these hair cells, by disease or damage, is a major cause of deafness. The decline of Neurofilaments can also lead to the cause of multiple sclerosis due to their neurological involvement. This new book brings fascinating research in this field.
Engrams
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Systems Neuroscience
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Molecular Mechanisms of Neurotransmitter Release
Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated c...
Microglia
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Basic and Translational Applications of the Network Theory for Dystonia
A recently proposed novel scheme of dystonia suggests that it is a disorder of neural network. Impairment in any of the “nodes” of the network may result in deficient network activity, causing dystonia. This book aims to present various experimental evidence supporting the network theory of dystonia. Dystonia is the abnormal twisting and turning of the organ and associated involuntary oscillations. Although dystonia is less common than Parkinson’s disease, traumatic brain injury, or stroke, each of these common disorders present with dystonia. Information regarding the brain regions that may be involved in dystonia is surprisingly limited and often conflicting. With chapters written by subject matter experts, this is a unique title that focuses on dystonia as a network disorder. This book would be of interest to basic and clinical researchers with an interest in motor systems and movement disorders.
Glycobiology of the Nervous System
This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.
