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Progress in Medicinal Chemistry
Progress in Medicinal Chemistry
Antineoplastic and Immunosuppressive Agents
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons ...
Immunotherapy for Gastrointestinal Cancer
This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
Antibiotics
None
Applied Biostatistical Principles and Concepts
The past three decades have witnessed modern advances in statistical modeling and evidence discovery in biomedical, clinical, and population-based research. With these advances come the challenges in accurate model stipulation and application of models in scientific evidence discovery Applied Biostatistical Principles and Concepts provides practical knowledge using biological and biochemical specimen/samples in order to understand health and disease processes at cellular, clinical, and population levels. Concepts and techniques provided will help researchers design and conduct studies, then translate data from bench to clinics in attempt to improve the health of patients and populations. This book is suitable for both clinicians and health or biological sciences students. It presents the reality in statistical modelling of health research data in a concise manner that will address the issue of "big data" type I error tolerance and probability value, effect size and confidence interval for precision, effect measure modification and interaction as well as confounders, thus allowing for more valid inferences and yielding results that are more reliable, valid and accurate.
Chemistry of Nucleosides and Nucleotides
This third of four volumes continues the work of its well-received predecessors by providing comprehensive articles on specific lines of research. All volumes are written with medicinal chemists, organic chemists, physical chemists, and biological chemists in mind. Additionally, with the spate of recent research on the anticancer, antiviral, and antiparasitic properties of nucleosides and nucleotides, the volumes will interest oncologists, virologists, and pharmacologists.
BICED 2020
The Faculty of Education and Teaching Institut Agama Islam Negeri (IAIN) Bukittinggi, West Sumatera Indonesia, organized the 2nd International Conference on Education (BICED 2020) on 14-15 September 2020 in Bukittinggi, West Sumatera, Indonesia. The number of participants who joined the zoom room was recorded at 736 participants. 224 participants attended the conference via the zoom application and 539 participants via YouTube Channel. Participants came from 5 countries, namely Indonesia, Malaysia, Kuala Lumpur, Brunei Darussalam, Thailand and Australia. BICED 2020 is implemented with the support of a stable internet network system and a zoom application. In the implementation there were sev...
Carbohydrates
Comprehensive Biochemisty, Volume 5: Carbohydrates deals with the organic and physical chemistry of the major organic constituents of living material. This book discusses the general structure of monosaccharides, detection and estimation of aldonic acids, intramolecular rearrangement of N-glycosides, and preparation of sugar phosphates. The deacetylation of glycoside acetates, naturally occurring oligosaccharides of human milk, and molecular weight of polysaccharides are also elaborated. This text likewise covers the biogenesis and fate of pectic substances in plant tissues, complex polysaccharides of gram-positive bacteria, galactosaminoglycan of Aspergillus parasiticus, and chemical structure of heparin sulfate. This volume is a good source for biochemists and researchers conducting work on carbohydrates.
Candidate Character Traits in Presidential Elections
Voter perceptions of the personal traits of presidential candidates are widely regarded to be important influences on the vote. Media pundits frequently explain the outcome of presidential elections in terms of the personal appeal of the candidates. Despite the emphasis on presidential character traits in the media, the scholarly investigation in this area is limited. In this book, David Holian and Charles Prysby set out to examine the effect that trait perceptions have on the vote, how these perceptions are shaped by other attitudes and evaluations, and what types of voters are most likely to cast a ballot on the basis of the character traits of the presidential candidates. Using the Americ...
Private Equity Investments
Private Equity experienced dramatic flutuations in investment activity in line with the turbulences of financial markets in recent years. Claudia Sommer develops a theoretical framework of factors driving private equity investment activity and the resulting performance implications. Using a data set of more than 40,000 European transations between 1990 and 2009 she applies a variety of econometrial approaches and shows how neoclassical aspects, information asymmetries, agency conflicts, and market timing contribute to the dynamics in the private equity market. In a performance analysis of more than 1,300 European private equity funds, she reveals how fund performance is linked to investment activity.
