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Epitranscriptomics: The Novel RNA Frontier
Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to iden...
Rutherford's Vascular Surgery, 2-Volume Set
Rutherford's Vascular Surgery - the most acclaimed comprehensive reference in its field - presents definitive, state-of-the-art guidance on every aspect of vascular health care, equipping you to make the best clinical decisions and optimize outcomes. Extensively revised by many new, international authors - led by Drs. Jack Cronenwett and K. Wayne Johnston - and now published in association with the Society for Vascular Surgery, this 7th Edition provides the authoritative answers that surgeons, interventionalists, and vascular medicine specialists need to provide effective care for vascular surgery patients. Consult this title on your favorite e-reader with intuitive search tools and adjustab...
Optical Nanoscopy and Novel Microscopy Techniques
Microscopy is at the forefront of multidisciplinary research. It was developed by physicists, made specific by chemists, and applied by biologists and doctors to better understand how the human body works. For this very reason, the field has been revolutionized in past decades. The objective of Optical Nanoscopy and Novel Microscopy Techniques is to choose some of those revolutionary ideas and serve a general audience from broad disciplines to achieve a fundamental understanding of these technologies and to better apply them in their daily research. The book begins with coverage of super-resolution optical microscopy, which discusses targeted modulation such as STED and SIM or localization m...
Textbook of Clinical Management of Club Drugs and Novel Psychoactive Substances
The only book to present the international evidence on harms and clinical management of club drugs and novel psychoactive substances.
The Nocturnal Trumpet
"The Nocturnal Trumpet" is comprised of fourteen short stories in the horror/fantasy genre. In "Spirits of Evil Past," you have the wax representations of four notorious historical figures who assume human form after being entered by their original spirits. The emotionally disturbed protagonist in "Flames" commits multiple acts of arson at the behest of a netherworld fire demon. A commercially successful pulp writer becomes the target of his most popular literary character in "The Vengeance of Silverhawk." "The Dark Heart of Fear" is an unconventional haunted house story in that the house is not haunted by ghosts but by its own sinister will and its need for human fear. "Written in Stone" ca...
Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds, volume II
This Research Topic is part of a series with: Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide, which is characterized by persistent, low-grade inflammation and is increased in the aging population. It occurs when an initiating stimulus is not removed or if the resolution process is disrupted, resulting in a state of low-grade inflammation. It is acknowledged that chronic inflammatory diseases are involved in cardiovascular diseases, endocrine disease, neurodegenerative disease, hepatic disease, pulmonary disease, gastrointestinal ...
Novel Therapeutic Proteins
This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology. Foreword written by Jürgen Drews.
