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The use of radical prostatectomy in patients with high risk of recurrence has significantly increased during the past 10 years. Thus, adjuvant radiation as a part of multimodality treatment or salvage radiation at the evidence of prostate-specific antigen (PSA) progression represents mainstay curative-intent options for a great number of prostate cancer patients. Although, few randomized trials and many retrospective studies have been published, many uncertainties still mold the discussions on the best treatment management for men after prostatectomy. This research topic successfully intended to foster discussions on current controversies in the use of postoperative radiotherapy and to present novel perspectives for treatment optimization.
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other em...
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Charles Longfellow, son of Henry Wadsworth Longfellow, arrived in Yokohama in 1871, intending a brief visit, and stayed for two years. He returned to Boston laden with photographs, curios, and art objects, as well as the elaborate tattoos he had "collected" on his body. His journals, correspondence, and art collection dramatically demonstrate America’s early impressions of Japanese culture, and his personal odyssey illustrates the impact on both countries of globetrotting tourism. Interweaving Longfellow’s experiences with broader issues of tourism and cultural authenticity, Christine Guth discusses the ideology of tourism and the place of Japan within nineteenth-century round-the-world travel. This study goes beyond simplistic models of reciprocal influence and authenticity to a more synergistic account of cross-cultural dynamics.
Volume XXVII/2 of History of Universities contains the customary mix of learned articles and book reviews which makes this publication such an indispensable tool for the historian of higher education. The volume is, as always, a lively combination of original research and invaluable reference material.
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
This description of Dominicans at Oxford from 1300-1350 and the theology of Hugh of Lawton, Arnold of Strelley, William Crathorn and Robert Holcot reclaims the Dominicans as highly original contributors to theology and philosophy at a time of great innovation.
In the ancient world being a philosopher was a practical alternative to being a christian. Philosophical systems offered intellectual, practical and moral codes for living. By the Middle Ages however philosophy was largely, though inconsistently, incorporated into Christian belef. From the end of the Roman Empire to the Reformation and Renaissance of the sixteenth century Christian theologians had a virtual monopoly on higher education. The complex interaction between theology and philosophy, which was the result of the efforts of Christian leaders and thinkers to assimilate the most sophisticated ideas of science and secular learning into their own system of thought, is the subject of this ...
This multi-authored volume, by an authoritative team of international scholars, examines the transmission of Ciceronian rhetoric in medieval and early Renaissance Europe, concentrating on the fortunes, in particular, of the two dominant classical rhetorical textbooks of the time, Cicero’s early De inventione, and the contemporary ‘pseudo-Ciceronian’ Rhetorica ad Herennium. The volume is unprecedented in range and depth as a presentation of the place of classical rhetoric in medieval culture, and will serve to revise views of a period seen until recently as largely indifferent to the values of ‘eloquence’. The main body of the volume is composed of a series of ground-breaking studie...