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There is now a range of cytotoxic drugs that have considerable clinical usefulness in producing responses in tumors and even, in a small proportion of cases, cure. However, the acquisition of drug resistance is a major clinical problem and is perhaps the main limiting factor in successful treatment of cancer. Thus, a tumor initially sensitive to chemotherapy will, in the majority of cases, eventually recur as a resistant tumor, which will then progress. Much of our understanding of drug resistance mechanisms comes from the study of tumor cell lines grown in tissue culture. We now understand many of the - lecular mechanisms that can lead to a cell acquiring resistance to antic- cer drugs; how...
Traditional African musical forms have long been accepted as fundamental to the emergence of blues and jazz. Yet there has been little effort at compiling recorded evidence to document their development. This discography brings together hundreds of recordings that trace in detail the evolution of the African American musical experience, from early wax cylinder recordings made in West Africa to voodoo rituals from the Carribean Basin to the songs of former slaves in the American South.
This comprehensive bibliography covers writings about vampires and related creatures from the 19th century to the present. More than 6,000 entries document the vampire's penetration of Western culture, from scholarly discourse, to popular culture, politics and cook books. Sections by topic list works covering various aspects, including general sources, folklore and history, vampires in literature, music and art, metaphorical vampires and the contemporary vampire community. Vampires from film and television--from Bela Lugosi's Dracula to Buffy the Vampire Slayer, True Blood and the Twilight Saga--are well represented.
The Theory of Architecture Concepts, Themes & Practices Paul-Alan Johnson Although it has long been thought that theory directs architectural practice, no one has explained precisely how the connection between theory and practice is supposed to work. This guide asserts that architectural theory does not direct practice, but is itself a form of reflective practice. Paul-Alan Johnson cuts through the jargon and mystery of architectural theory to clarify how it relates to actual applications in the field. He also reveals the connections between new and old ideas to enhance the reader's powers of critical evaluation. Nearly 100 major concepts, themes, and practices of architecture--as well as th...
Fourteen-year-old George Harrison emigrated from England to Utah in 1856. He was part of a Mormon family relocating to "Zion" for both religious and economic reasons. The young man, suffering from malaria and extreme food shortages in the Martin Handcart Company, abandoned his family and spent a winter with a compassionate Indian family that saved him from starvation. Soon after, at Fort Laramie, Harrison served as a civilian cook for an army surgeon. He accompanied troops during the march into Salt Lake City in 1858 and cooked at Camp Floyd. Upon the camp's closure in 1861, he cooked at an Overland Stage and Pony Express station. George Harrison subsequently worked as a freighter and served in the Black Hawk War. In mid-life he built a small restaurant and hotel in Springville, Utah. Harrison's cooking, singing, and story telling attracted "drummers" (traveling salesmen) who gave the restaurateur the name of "Beefsteak" because of the quality of his steaks.
Chiang Mai (literally, “new city”) suffered badly in the 1997 Asian financial crisis as the Northern Thai real estate bubble collapsed along with the Thai baht, crushing dreams of a renaissance of Northern prosperity. Years later, the ruins of the excesses of the 1990s still stain the skyline. In Ghosts of the New City, Andrew Alan Johnson shows how the trauma of the crash, brought back vividly by the political crisis of 2006, haunts efforts to remake the city. For many Chiang Mai residents, new developments harbor the seeds of the crash, which manifest themselves in anxious stories of ghosts and criminals who conceal themselves behind the city’s progressive veneer. Hopes for rebirth a...