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Vaccines
Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety...recommendations for vaccine use, with rationales...data on the impact of vaccination programs on morbidity and mortality...and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most! Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as w...
Veterinary Vaccines
Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine that enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have ...
Special Reports
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Diseases and Human Evolution
Urgent interest in new diseases, such as the coronavirus, and the resurgence of older diseases like tuberculosis has fostered questions about the history of human infectious diseases. How did they evolve? Where did they originate? What natural factors have stalled the progression of diseases or made them possible? How does a microorganism become a pathogen? How have infectious diseases changed through time? What can we do to control their occurrence? ; Ethne Barnes offers answers to these questions, using information from history and medicine as well as from anthropology. She focuses on changes in the patterns of human behavior through cultural evolution and how they have affected the develo...
Emerging Diseases
Researchers are still identifying micro-organisms that cause new diseases in humans. A basic factor in the emergence of these diseases is the role played by animals, which act as a reservoir for certain viruses. In favourable conditions, such viruses can cross the species barrier and infect humans. The book takes a close look at two families of virus: orthomyxoviridae and paramyxoviridae, which have infected many species of vertebrates and are responsible for zoonosis. The two main parts of the book describe how the viruses operate, how they spread and the risk factors for humans. In addition to a specific and detailed study of these two micro-organisms, the book highlights the fascinating history of such diseases, their emergence, development and disappearance. They have occurred throughout human history, underscoring the role of the environment and the way it changes, often as a result of human intervention. Sponsored by the Mérieux Foundation and written by leading international specialists, this book provides first-class information about these new viruses.
Zoonoses: Infections Affecting Humans and Animals
This second fully revised and extended edition of “Zoonoses - Infections Affecting Humans and Animals” covers the most important pathogens impacting both human and animal public health and debates current developments in this interdisciplinary field from a One Health perspective. Following a "setting" approach, the individual chapters each review zoonoses occurring in a specific group of animals, such as production animals, pets or wildlife, or in a defined ecosystem. A focus is put on zoonoses emerging along the food chain and on antibiotic resistance as an increasing challenge in infectious disease management. Special interest chapters debate non-resolved and currently hotly debated zo...
Infectious Disease Ecology
News headlines are forever reporting diseases that take huge tolls on humans, wildlife, domestic animals, and both cultivated and native plants worldwide. These diseases can also completely transform the ecosystems that feed us and provide us with other critical benefits, from flood control to water purification. And yet diseases sometimes serve to maintain the structure and function of the ecosystems on which humans depend. Gathering thirteen essays by forty leading experts who convened at the Cary Conference at the Institute of Ecosystem Studies in 2005, this book develops an integrated framework for understanding where these diseases come from, what ecological factors influence their impa...
Virus Discovery by Metagenomics: The (Im)possibilities
Since the late 1800s, the discovery of new viruses was a gradual process. Viruses were described one by one using a suite of techniques such as (electron) microscopy and viral culture. Investigators were usually interested in a disease state within an organism, and expeditions in viral ecology were rare. The advent of metagenomics using high-throughput sequencing has revolutionized not only the rate of virus discovery, but also the nature of the discoveries. For example, the viral ecology and etiology of many human diseases are being characterized, non-pathogenic viral commensals are ubiquitous, and the description of environmental viromes is making progress. This Frontiers in Virology Research Topic showcases how metagenomic and bioinformatic approaches have been combined to discover, classify and characterize novel viruses.
