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PET and SPECT of Neurobiological Systems
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
Current Aspects of Radiopharmaceutical Chemistry
This book is a printed edition of the Special Issue "Current Aspects of Radiopharmaceutical Chemistry" that was published in Molecules
The Histamine H3 Receptor
In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). B...
Novel Phytopharmaceutical for Management of Disorders
Novel Phytopharmaceutical for Management of Disorders covers recent advances surrounding phytopharmaceuticals and their potential uses in the management of several disorders as well as in cosmetic benefits. Sections cover the concepts of phytopharmaceuticals and current highlights in disease management. This book also emphasizes phytopharmaceutical drug delivery studies in vivo–in vitro study to various target organs like lungs, liver, and brain. This book provides key information for everyone interested in disease management, drug discovery, and delivery, including medicinal chemists, cosmetic experts, nutritionists, toxicologists, drug formulators, and health care professionals. Students...
Radiopharmaceutical Chemistry
This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on t...
Positron Emission Tomography
This detailed volume explores key concepts and experimental design related to Positron Emission Tomography (PET) imaging that have revolutionized our understanding of human biology. The first part focuses on recent advances in radiotracer probe development to enable the detection of materials, from large macromolecules to complicated drug-like structures. The next section describes how key physiological and pathophysiological processes can be interrogated and quantifiably measured with this imaging technique. Finally, chapters examine important technological developments in the field that are revolutionizing the way these innovative PET probes are utilized in the clinic. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Positron Emission Tomography: Methods and Protocols serves as an ideal guide for researchers looking to use imaging to revolutionize the way we diagnose and treat disease.
A Milestone in Frontiers in Pharmacology: 1,000 Published Papers in the Section Experimental Pharmacology and Drug Discovery
Frontiers in Pharmacology was launched in 2010, with a number of sections which were eventually reorganized. The founding Field Chief Editor was Prof. Théophile Godfraind, an eminent scientist active in cardiovascular pharmacology, who pioneered the discovery of calcium antagonists. At that time he invited me to serve as Chief Editor for a section named “Analytical and Experimental Pharmacology”. Later on, our section enlarged and was re-named as “Experimental Pharmacology and Drug Discovery” to outline the translational potential of fundamental pharmacological research and theoretical analysis to the improvement of human health, through the invention of novel medicinal products. We are now entering the 10th year of editorial activity, which sees the publication of the 1,000th paper in our section. Such an achievement is very rewarding for us and our community, but it is even more remarkable when placed into the timeline of our development. In fact, in a 10-year frame we have significantly grown in quantity and quality, e.g. both in number of published papers and in scientific impact. [From a personal perspective by Salvatore Salomone, Specialty Chief Editor]
Your Cannabis CBD:THC Ratio
The author of the game-changing Cannabis Health Index returns with a book designed specifically for general readers who want to understand how THC and CBD can benefit them. While CBD is the new buzzword for health and wellness, many researchers and practitioners believe that the symbiotic relationship between THC and CBD, known as the entourage effect, allows for greater therapeutic benefits for patients. Unfortunately, when it comes to optimizing that ratio to a particular health condition, it is often a process of trial and error for medical patients. Your Cannabis CBD:THC Ratio provides detailed information on how to find the best ratios of CBD:THC and covers the preferred ratios of these two primary cannabinoids for ten prevalent medical conditions —including cancer, chronic pain, anxiety, insomnia, and many others. Blesching’s unique chemotype-based system takes into account CBD:THC ratios, the various forms of cannabis medicine available to consumers, and the subjective therapeutic dosages, presenting a complete evidence-based methodology. -- Uwe Blesching, PH.D.
