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New Challenges for Cancer Systems Biomedicine
The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.
Modeling the Interplay Between Human Behavior and the Spread of Infectious Diseases
This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.
Mathematical Methods and Models in Biomedicine
Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phe...
Bounded Noises in Physics, Biology, and Engineering
Since the parameters in dynamical systems of biological interest are inherently positive and bounded, bounded noises are a natural way to model the realistic stochastic fluctuations of a biological system that are caused by its interaction with the external world. Bounded Noises in Physics, Biology, and Engineering is the first contributed volume devoted to the modeling of bounded noises in theoretical and applied statistical mechanics, quantitative biology, and mathematical physics. It gives an overview of the current state-of-the-art and is intended to stimulate further research. The volume is organized in four parts. The first part presents the main kinds of bounded noises and their...
Fifty Years of Quasars
Formatted as a series of interviews with noted researchers in the field, this book reviews the history of quasar research and describes how advances in instrumentation and computation have aided quasar astronomy and changed our basic understanding of quasars.
Systems Biology of Tumor Dormancy
This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling.
Aspects of Mathematical Modelling
The construction of mathematical models is an essential scientific activity. Mathematics is associated with developments in science and engineering, but more recently mathematical modelling has been used to investigate complex systems that arise in other fields. This book demonstrates the application of mathematics to research topics in ecology and environmental science, health and medicine, phylogenetics and neural networks, theoretical chemistry, economics and management.
Mathematical Modelling and Computational Intelligence Techniques
This book collects papers presented at the International Conference on Mathematical Modelling and Computational Intelligence Techniques (ICMMCIT) 2021, held at the Department of Mathematics, The Gandhigram Rural Institute (Deemed to be University), Gandhigram, Tamil Nadu, India, from 10–12 February 2021. Significant contributions from renowned researchers from fields of applied analysis, mathematical modelling and computing techniques have been received for this conference. Chapters emphasize on the research of computational nature focusing on new algorithms, their analysis and numerical results, as well as applications in physical, biological, social, and behavioural sciences. The accepted papers are organized in topical sections as mathematical modelling, image processing, control theory, graphs and networks, and inventory control.
An Introduction to Continuous-Time Stochastic Processes
This textbook, now in its fourth edition, offers a rigorous and self-contained introduction to the theory of continuous-time stochastic processes, stochastic integrals, and stochastic differential equations. Expertly balancing theory and applications, it features concrete examples of modeling real-world problems from biology, medicine, finance, and insurance using stochastic methods. No previous knowledge of stochastic processes is required. Unlike other books on stochastic methods that specialize in a specific field of applications, this volume examines the ways in which similar stochastic methods can be applied across different fields. Beginning with the fundamentals of probability, the au...
