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The Role of Glia in Alzheimer's Disease
We believe that the role of glia is the next frontier to be explored in Alzheimer’s disease research. This eBook is an update on both the current knowledge of astrocytes and microglia involvement in Alzheimer’s disease pathophysiology, and some of the techniques available to study them.
The Wiley Handbook on the Aging Mind and Brain
A thought-provoking treatise on understanding and treating the aging mind and brain This handbook recognizes the critical issues surrounding mind and brain health by tackling overarching and pragmatic needs so as to better understand these multifaceted issues. This includes summarizing and synthesizing critical evidence, approaches, and strategies from multidisciplinary research—all of which have advanced our understanding of the neural substrates of attention, perception, memory, language, decision-making, motor behavior, social cognition, emotion, and other mental functions. Written by a plethora of health experts from around the world, The Wiley Handbook on the Aging Mind and Brain offe...
Neurobiology of Disease
Preceded by Neurobiology of disease / edited by Sid Gilman. 2007.
Trialectic
"Emerging neuroscientific insights are changing our understanding of what it means to be human. The resulting reconceptualization continues to impact law and the fit between law and morality. This book takes account of those developments and suggests that normative theory, particularly in its non-instrumental iterations, will be challenged, most profoundly. If we are, as the science suggests, nothing more than the coincidence of mechanical forces, then law and normative theory that depend on the immaterial and that would draw distinctions between the "mental" or "emotional" and the more manifestly physical are misguided, so misguided that they would actually undermine human thriving. Indeed, they already do. The ramifications of that conclusion are profound. Trialectic posits and investigates the impact of those ramifications on law"--
Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sc...
Signal Transduction Immunohistochemistry
This new edition collects diverse protocols compiled by experts from different areas of research as well as by biotech researchers developing novel technologies in the area of immunohistochemistry (IHC). After a few chapters to help orient novices entering the biomedical arena, the book includes methods chapters covering multiplex IHC including fluorescence and chromogenic techniques, combination of IHC with In Situ Hybridization (ISH), wavelet transform approach for organelle tracking, transcription factors in human stem cells, differentiation of mesenchymal stem cells, 3D imaging, phenotyping of glial cells in the human brain, tissue fixation, permeabilization, and cryo-preservation, as we...
