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Cutting Edge Preclinical Models in Translational Medicine
In vitro, in vivo, and in silico preclinical models hold a widely acknowledged potential, yet complex limitations. For this reason, which has been known for a long time by experimenters and modelers, the translation of “science products” to the clinic is still far. Therefore, there is a raising awareness of the need to bridge this gap by developing integrated and innovative models. Organ and tissue bioengineering is an ideal approach to foster innovative strategies in significant research and clinical areas. Similarly, in translational neuroscience research, this challenge has been taken up by intriguing fish models. However, much research based on novel methodologies has still to be performed to get the bench closer to the bedside.
Regeneration and Plasticity in the Mammalian Visual System
This fourth volume in the Retina Research Foundation Symposia Proceedings highlights several of the strategies and experimental paradigms that are currently used to exploit and amplify the regenerative capacity of the adult mammalian visual system, and reviews the exciting advances being made in understanding the molecular basis of central nervous system regeneration.Because loss of neurons or interruptions of their connective pathways in the mammalian visual system can, in contrast to certain amphibians and fish, lead to permanent loss of vision, studies of regeneration and plasticity in this system serve as valuable models for the reconstitution of other parts of the nervous system and as ...
The Longevity Factor
A groundbreaking examination of new scientific research that holds the secret to weight loss, increased strength, endurance, memory, and a healthier, longer life In The Longevity Factor, noted neuroscientist and surgeon Joseph Maroon, M.D., offers the definitive look at recent scientific breakthroughs identifying a group of natural substances -- including the much-publicized molecule resveratrol -- that can actually activate a specific set of genes in humans that promote a longer, healthier life. These substances, which make red wine, dark chocolate, and green tea good for us, appear to stave off a wide array of age-related diseases and keep us feeling young and vital. Resveratrol is the cen...
Cerebral Plasticity
A survey of the latest research, covering such topics as plasticity in the adult brain and the underlying mechanisms of plasticity. The notion that neurons in the living brain can change in response to experience—a phenomenon known as "plasticity"—has become a major conceptual issue in neuroscience research as well as a practical focus for the fields of neural rehabilitation and neurodegenerative disease. Early work dealt with the plasticity of the developing brain and demonstrated the critical role played by sensory experience in normal development. Two broader themes have emerged in recent studies: the plasticity of the adult brain (one of the most rapidly developing areas of current r...
Hormonal Therapy for Male Sexual Dysfunction
Hormonal therapy offers a potentially powerful approach to the treatment of sexual disorders in men. However the interplay of different hormones within different bodily systems is carefully balanced; judicious judgement is required in the therapeutic use of hormones to minimize unwelcome side effects. A better understanding of how hormones work will help the physician to better tailor therapies for improved sexual responses in men. Hormonal Therapy for Male Sexual Dysfunction will provide the rationale for hormonal therapy in male sexual disorders, explaining the language of sexual endocrinology and its application in clinical practice. The aim of this book is to provide a clinical 'in the o...
Evolution, Development and Ecology of Anemonefishes
Anemonefishes, one of the most popular and recognizable of fishes in the world, are much more than film characters; they are also emerging model organisms for studying the biology, ecology, and evolution of coral reef fishes. They are a group of 28 species often employed to study patterns and processes of social organization, intra- and inter-specific competition, sex change, mutualism, dispersal and connectivity of fish populations, habitat selection, pigment pattern formation, lifespan and predator-prey interactions. This multi-authored book covers all these areas and provides an update on the research done with this model and the perspective it opens for the future. Key Features Contains basic and up-to-date information on an emerging fish model Allows non-specialist readers to grasp the relevance of a wide research area Provides accurate and easy to access information on each of the 28 species Includes guidance for establishing a breeding colony Documents that anemonefishes are useful model organisms for ecological, developmental and climate research
On Sex and Gender
An eye-opening account of what the left and right get wrong about sex and gender—and how we can be a thoughtful, sex-smart society. On Sex and Gender focuses on three sequential and consequential questions: What is sex as opposed to gender? How does sex matter in our everyday lives? And how should it be reflected in law and policy? All three have been front-and-center in American life and politics since the rise of the trans rights movement: They are included in both major parties’ political platforms. They are the subject of ongoing litigation in the federal courts and of highly contentious legislation on Capitol Hill. And they are a pivotal issue in the culture wars between left and ri...
Life and Death in the Nervous System
Life and Death in the Nervous System
Life-Span Extension
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and...
