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Cutting Edge Preclinical Models in Translational Medicine
  • Language: en
  • Pages: 262

Cutting Edge Preclinical Models in Translational Medicine

  • Type: Book
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  • Published: 2020-12-10
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  • Publisher: MDPI

In vitro, in vivo, and in silico preclinical models hold a widely acknowledged potential, yet complex limitations. For this reason, which has been known for a long time by experimenters and modelers, the translation of “science products” to the clinic is still far. Therefore, there is a raising awareness of the need to bridge this gap by developing integrated and innovative models. Organ and tissue bioengineering is an ideal approach to foster innovative strategies in significant research and clinical areas. Similarly, in translational neuroscience research, this challenge has been taken up by intriguing fish models. However, much research based on novel methodologies has still to be performed to get the bench closer to the bedside.

Hormonal Therapy for Male Sexual Dysfunction
  • Language: en
  • Pages: 144

Hormonal Therapy for Male Sexual Dysfunction

Hormonal therapy offers a potentially powerful approach to the treatment of sexual disorders in men. However the interplay of different hormones within different bodily systems is carefully balanced; judicious judgement is required in the therapeutic use of hormones to minimize unwelcome side effects. A better understanding of how hormones work will help the physician to better tailor therapies for improved sexual responses in men. Hormonal Therapy for Male Sexual Dysfunction will provide the rationale for hormonal therapy in male sexual disorders, explaining the language of sexual endocrinology and its application in clinical practice. The aim of this book is to provide a clinical 'in the o...

Cerebral Plasticity
  • Language: en
  • Pages: 439

Cerebral Plasticity

  • Type: Book
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  • Published: 2011-05-20
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  • Publisher: MIT Press

A survey of the latest research, covering such topics as plasticity in the adult brain and the underlying mechanisms of plasticity. The notion that neurons in the living brain can change in response to experience—a phenomenon known as "plasticity"—has become a major conceptual issue in neuroscience research as well as a practical focus for the fields of neural rehabilitation and neurodegenerative disease. Early work dealt with the plasticity of the developing brain and demonstrated the critical role played by sensory experience in normal development. Two broader themes have emerged in recent studies: the plasticity of the adult brain (one of the most rapidly developing areas of current r...

The Longevity Factor
  • Language: en
  • Pages: 370

The Longevity Factor

Neuroscientist and surgeon Joseph Maroon looks at recent scientific breakthroughs identifying a group of natural substances--including the much-publicized molecule resveratrol--that can actually activate a specific set of genes that promote a longer, healthier life. These substances, which make red wine, dark chocolate, and green tea good for us, appear to stave off a wide array of age-related diseases and keep us feeling young and vital. Only recently have scientists discovered how to isolate resveratrol and concentrate it into an affordable and safe supplement. Already, more than 200 supplements featuring resveratrol have flooded the market, and there are more on the way. What is a consumer to look for? Since resveratrol is a natural substance, can you get enough of it through diet alone, or should you combine diet with a supplement? And what lies on the horizon from the pharmaceutical industry? These questions and many more are answered here. --From publisher description.

Regeneration and Plasticity in the Mammalian Visual System
  • Language: en
  • Pages: 276

Regeneration and Plasticity in the Mammalian Visual System

  • Type: Book
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  • Published: 1992
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  • Publisher: MIT Press

This fourth volume in the Retina Research Foundation Symposia Proceedings highlights several of the strategies and experimental paradigms that are currently used to exploit and amplify the regenerative capacity of the adult mammalian visual system, and reviews the exciting advances being made in understanding the molecular basis of central nervous system regeneration.Because loss of neurons or interruptions of their connective pathways in the mammalian visual system can, in contrast to certain amphibians and fish, lead to permanent loss of vision, studies of regeneration and plasticity in this system serve as valuable models for the reconstitution of other parts of the nervous system and as ...

On Sex and Gender
  • Language: en
  • Pages: 336

On Sex and Gender

An eye-opening account of what the left and right get wrong about sex and gender—and how we can be a thoughtful, sex-smart society. On Sex and Gender focuses on three sequential and consequential questions: What is sex as opposed to gender? How does sex matter in our everyday lives? And how should it be reflected in law and policy? All three have been front-and-center in American life and politics since the rise of the trans rights movement: They are included in both major parties’ political platforms. They are the subject of ongoing litigation in the federal courts and of highly contentious legislation on Capitol Hill. And they are a pivotal issue in the culture wars between left and ri...

Life and Death in the Nervous System
  • Language: en
  • Pages: 499

Life and Death in the Nervous System

Life and Death in the Nervous System

Gender Identity in International Law
  • Language: en
  • Pages: 322

Gender Identity in International Law

  • Categories: Law

The book considers the genealogy of the term gender identity and its entrance and development in international human rights law. Going against the prevailing narrative, the book explores the possibility of refashioning gender identity as a belief; this reframing allows the conflicting rights of women, children and LGB people to be protected and as well as the right of people to express their belief in having a gender identity incongruent with their sex.

Life-Span Extension
  • Language: en
  • Pages: 203

Life-Span Extension

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and...

Multicellularity: Views from cellular signaling and mechanics
  • Language: en
  • Pages: 139