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Mathematical Modelling of Chromosome Replication and Replicative Stress
DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?. A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.
Applications of Chaos and Nonlinear Dynamics in Engineering -
Chaos and nonlinear dynamics initially developed as a new emergent field with its foundation in physics and applied mathematics. The highly generic, interdisciplinary quality of the insights gained in the last few decades has spawned myriad applications in almost all branches of science and technology—and even well beyond. Wherever quantitative modeling and analysis of complex, nonlinear phenomena is required, chaos theory and its methods can play a key role. This volume concentrates on reviewing the most relevant contemporary applications of chaotic nonlinear systems as they apply to the various cutting-edge branches of engineering. The book covers the theory as applied to robotics, electronic and communication engineering (for example chaos synchronization and cryptography) as well as to civil and mechanical engineering, where its use in damage monitoring and control is explored). Featuring contributions from active and leading research groups, this collection is ideal both as a reference and as a ‘recipe book’ full of tried and tested, successful engineering applications
Bounded Noises in Physics, Biology, and Engineering
Since the parameters in dynamical systems of biological interest are inherently positive and bounded, bounded noises are a natural way to model the realistic stochastic fluctuations of a biological system that are caused by its interaction with the external world. Bounded Noises in Physics, Biology, and Engineering is the first contributed volume devoted to the modeling of bounded noises in theoretical and applied statistical mechanics, quantitative biology, and mathematical physics. It gives an overview of the current state-of-the-art and is intended to stimulate further research. The volume is organized in four parts. The first part presents the main kinds of bounded noises and their...
Toward an Anthropology of Screens
This book shows that screens don’t just distribute the visible and the invisible, but have always mediated our body's relationships with the physical and anthropological-cultural environment. By combining a series of historical-genealogical reconstructions going back to prehistoric times with the analysis of present and near-future technologies, the authors show that screens have always incorporated not only the hiding/showing functions but also the protecting/exposing ones, as the Covid-19 pandemic retaught us. The intertwining of these functions allows the authors to criticize the mainstream ideas of images as inseparable from screens, of words as opposed to images, and of what they call “Transparency 2.0” ideology, which currently dominates our socio-political life. Moreover, they show how wearable technologies don’t approximate us to a presumed disappearance of screens but seem to draw a circular pathway back to using our bodies as screens. This raises new relational, ethical, and political questions, which this book helps to illuminate.
Automated Deduction -- CADE-23
This book constitutes the refereed proceedings of the 23rd International Conference on Automated Deduction, CADE-23, held in Wrocław, Poland, in July/August 2011. The 28 revised full papers and 7 system descriptions presented were carefully reviewed and selected from 80 submissions. Furthermore, four invited lectures by distinguished experts in the area were included. Among the topics addressed are systems and tools for automated reasoning, rewriting logics, security protocol verification, unification, theorem proving, clause elimination, SAT, satifiability, interactive theorem proving, theory reasoning, static analysis, decision procedures, etc.
Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a genera...
Genealogia Das Famílias Moreira Maia E Ferreira Dos Reis
A obra teve por fundamentação o fato inédito de famílias cristalenses: Moreira Maia e Ferreira dos Reis se originarem de dois padres. A história é tecida ao longo de três séculos:final do século XIX, século XX e início do século XXI.
Abitare la Terra n.29/2011 - Dwelling on Earth
EDUARDO SOUTO DE MOURA Luca Nicotera ALESSANDRO ANSELMI Stefania Tuzi LAKE|FLATO Maria Luna Vetrani ANTONIO MONESTIROLI Gaetano Fusco BOGDAN BOGDANOVIC Slobodan Selinkic CINO ZUCCHI Alessandra Sgueglia EMILIO CARAVATTI Pietro Fantozzi SUONI DI PIETRA / SOUNDS OF STONE Adriana Rossi CONSIDERAZIONI SULL’URBANISTICA A ROMA / THOUGHTS ABOUT URBAN PLANNING IN ROME Carlo Maltese INTERVISTA A CARLO PETRINI / INTERVIEW WITH CARLO PETRINI Mario Pisani
Black Holes
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Artificial Immune Systems
Arti?cial immune systems (AIS) is a diverse and maturing area of research that bridges the disciplines of immunology and engineering. The scope of AIS ranges fromimmune-inspiredalgorithmsandengineeringsolutionsinsoftwareandha- ware, to the understanding of immunology through modeling and simulation of immune system concepts. AIS algorithms have been applied to a wide variety of applications, including computer security, fault tolerance, data mining and optimization. In addition, theoretical aspects of arti?cial and real immune s- tems have been the subject of mathematical and computational models and simulations. The 8th InternationalConference on AIS (ICARIS 2009)built on the success of previous years, providing a forum for a diverse group of AIS researchers to present and discuss their latest results and advances. After two years outside Europe, ICARIS 2009 returned to England, the venue for the ?rst ICARIS back in 2002. This year’s conference was located in the historic city of York, and was held in St. William’s College, the conference venue of York Minster, northern Europe’s largest Gothic cathedral.
