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Poly(ADP-Ribosyl)ation
This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
High-Throughput Screening Methods in Toxicity Testing
Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's "Toxicity Testing in the 21st Century: A Vision and Strategy" and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testin...
PARP Inhibitors for Cancer Therapy
PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
How Do Emotions and Feelings Regulate Physical Activity?
Up to date the scientific discussion about how frequency and regularity of physical activity can be increased is dominated by social-cognitive models. However, increasing evidence suggests that emotions and feelings have greater influence on physical activity than originally assumed (Rhodes, Fiala, & Conner, 2009). Generally speaking, humans possess an evaluative system with a basic action tendency to approach pleasurable events and to avoid aversive ones (Cacioppo & Berntson, 1999). Evaluative responses to a behavior and associated emotional states may influence a decision regarding whether or not to repeat being physically active. Generally, behavior associated with positive evaluations ha...
Reach for the Stars
Wrestling is as much a part of winter in Iowa as is snow and cold. Dreams of state championships begin in elementary school and, since 1972, come to fruition-or heartbreakingly fall short-at an arena in Des Moines in February or March. The tournament finals sell out, and individuals and teams carve their names on the sport's history tree each year. Some champions were deaf, some were amputees, but all earn the respect of thousands for their work ethic-a hallmark of the state's populace. Is this heaven? No, it's better than that. It's high school wrestling in Iowa!
Who Owns Whom
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Kunststraßen
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Der fünfte BMW Art Guide by Independent Collectors
Der überarbeitete und erweiterte BMW Art Guide by Independent Collectors präsentiert fast 300 öffentlich zugängliche Privatsammlungen zeitgenössischer Kunst – große wie kleine, bekannte wie noch unentdeckte. Die prägnanten Sammlungsporträts mit zahlreichen farbigen Abbildungen entführen den Leser in mehr als vierzig Länder und häufig in Regionen oder Stadtviertel abseits des Gewohnten. Dieser praktische Guide ist die gemeinschaftliche Publikation, die aus der seit einigen Jahren bestehenden Partnerschaft zwischen BMW und Independent Collectors, der internationale Online-Plattform für Sammler zeitgenössischer Kunst hervorgegangen ist. Sammler, Galeristen, Künstler und Journalisten halfen bei der umfassenden Recherche und Überarbeitung des einmaligen Standardwerks. Weder im Internet noch in Buchform existiert bislang eine vergleichbare Zusammenstellung von internationalen Privatkollektionen, darunter einige, die ihre Türen für Kunstinteressierte und Kenner erstmalig öffnen.
