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TRAF Proteins in Human Disease
Tumor necrosis factor receptor (TNFR) associated factors (TRAFs) are a family of signaling adaptors first identified as components of TNFR signaling complexes, but now recognized to regulate signal transduction downstream of a diverse array of receptors, including Toll like receptors, antigen receptors and cytokine receptors. TRAF proteins play important roles in many human diseases and processes as both positive and negative regulators. This eBook begins with a review of TRAF structure, followed by reviews on the role of TRAFs in NF-kB and mitogen activated protein kinase (MAPK) signaling as well as in signaling downstream of innate pattern recognition receptors. Next is a review focused on...
Cancer Care in Areas of Conflict
Cancer is a global burden with more than 18 million diagnosed and an estimate of 10 million deaths in 2020 worldwide. Cancer continues to be a major and growing problem in conflict affected areas too. The incidence of cancer is expected to rise significantly in those countries compared to the rest of the world. Conflict, massive migration and displacement has put a tremendous pressure on all health care systems and health economy which halted improvement in many cancer care in majority of the countries. Countries affected by conflict like Syria, Ukraine, Iraq, Yemen, Latin America and others has led to destruction of the whole countries healthcare infrastructure including health care facilit...
Jak-Stat Signaling : From Basics to Disease
JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Encyclopedia of Immunobiology
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
The Poetics of Arabian Sūqs
This book investigates the history of Arabian sūqs from their pre-Islamic beginnings to the present. Collecting evidence from archaeological ruins, Islamic towns, modern cities, Arabic poetry, philosophical debates, political conflicts, puppet shows and the insights of modern-day market-goers, the book presents new and unforeseen interpretations of the Arabian sūq’s meaning and its transformation through time and place. The finding that such meaning is tied to ancient trade rituals, where temple and market presented a holistic socio-urban unit, re-questions some instrumental assumptions regarding the value of sūq-ness in Arabia’s everyday practices. Such a finding, which locates the fadaā/tareeq duality as a central theme in Arabia’s socio-urban discourse, emphasizes the importance of lived experiences and poetics as key sources for understanding socio-urban phenomena.
Cancer in the Arab World
This is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab wo...
Texts in Transit in the Medieval Mediterranean
This collection of essays studies the movement of texts in the Mediterranean basin in the medieval period from historical and philological perspectives. Rejecting the presumption that texts simply travel without changing, the contributors examine closely the nature of these writings, which are concerned with such topics as science and medicine, and how they changed over the course of their journeys. Transit and transformation give texts new subtexts and contexts, providing windows through which to study how memory, encryption, oral communication, cultural and religious values, and knowledge traveled and were shared, transformed, and preserved. This volume broadens how we think about texts, communication, and knowledge in the medieval world. Aside from the editors, the contributors are Mushegh Asatryan, Brian N. Becker, Leonardo Capezzone, Leigh Chipman, Ofer Elior, Zohar Hadromi-Allouche, B. Harun Küçük, Israel M. Sandman, and Tamás Visi.
Phytoplasma Diseases of Major Crops, Trees, and Weeds
Phytoplasma Diseases of Major Crops, Trees, and Weeds is the second volume in a three-volume series dedicated to the analysis of plant pathogenic phytoplasmas across Asia. With a close look into the different types of plants affected by phytoplasma, the book offers management strategies to develop resistant plant strains. Phytoplasma diseases pose serious economic losses in many Asian countries, for which there is very little awareness within society. The chapters in Volume 2 comprehensively review predominant plant species and how they are impacted by phytoplasma diseases, providing information on host-pathogen interaction, characterization, and genetic diversity. The Phytoplasma Diseases i...
