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Recent Advances on Quinazoline
This book investigates and identifies novel therapeutic compounds for the treatment of a range of illnesses. Heterocyclic compounds are a significant class of substances with biological activity. Among them, quinazoline has attracted a lot of interest because of its important biological properties. Numerous compounds with quinazoline moiety have been shown to exhibit a wide range of therapeutic properties, including antioxidant, antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, and antibacterial activities. This book presents a comprehensive overview of quinazoline and its derivatives. The chapters address recent advances in the synthesis of several different heterocyclic compounds, the use of computational studies for finding new active quinazoline derivatives, the biological activities of quinazoline, and much more.
Quinazolinone and Quinazoline Derivatives
One of the problems with modern public health is target searching for new highly effective medicinal preparations. Among those medicinal preparations are the natural and synthetic origins of quinazolinone-4 derivatives. Quinazolinone derivatives are reported to be physiologically and pharmacologically active. They also exhibit a wide range of activities such as anticonvulsant, antiinflammatory, antifungal, antimalarial, and sedative properties. Some of these compounds are identified as drugs used as diuretics, vasodilators, and antihypertensive agents. Moreover, sulfonamide derivatives have been widely used as bacteriostatic agents. Prompted by the above-mentioned facts and in conjunction with our ongoing program on the utility of readily obtainable starting material for the synthesis of heterocyclic systems of biological interest, we have decided to synthesize a series of quinazolinone derivatives having sulfonamide moiety with a potentially wide spectrum of biological responses.
Corticosteroids
Corticosteroids are mainly used to reduce inflammation and suppress the immune system. Corticosteroids will only be prescribed if the potential benefits of treatment outweigh the risks. They will also be prescribed at the lowest effective dose for the shortest possible time. This book will strive to highlight the importance of corticosteroids, to focus on minimizing side effects, to monitor and sensitize the population on the potential adverse effects of misuse, to provide additional knowledge about the design and development of new drug delivery systems loaded with corticosteroids potentially useful in the treatment of chronic inflammatory-based diseases, and to reduce inflammation and affect the immune system. The major objective of this book will be to present the information in a lucid, condensed, and cohesive form and to specially cater to the needs of readers in medicine and pharmacy.
Nonsteroidal Anti-Inflammatory Drugs
This book intends to provide the reader with a comprehensive overview about the state of the art regarding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in physical and rehabilitation medicine and the study of the pharmacodynamics of existing and newly introduced NSAIDs in the management of pain and inflammation. It will also elaborate and refine already known knowledge on the mechanism(s) of nonsteroidal anti-inflammatory agents. This book may provide additional knowledge about the design and development of new drug delivery systems loaded with NSAIDs potentially useful in the treatment of chronic inflammatory-based diseases following circadian cycle, uses of NSAIDs as a source of medicinal plants, and the adverse effects and drug interactions of the nonsteroidal anti-inflammatory drugs.
Rare Neurodegenerative Disorders - New Insights
Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every neurodegenerative disorder. The particular system affected, more importantly the distribution of the pathology, determines the clinical presentation. While the most common dementia and movement disorders, such as Alzheimer’s disease, Lewy body disease, and frontotemporal lobar degeneration with TDP-43 pathology, including amyotrophic lateral sclerosis, have been extensively studied, many less comm...
Adrenal Glands
The book presents an in-depth exploration of adrenal anatomy, physiology, and pathology, authored by a multidisciplinary team of international experts, providing an exposition of the current state of knowledge in the field of adrenal diseases and offering insights into the evolution of their management. The addressed pathologies are intricate and diverse, encompassing conditions such as Cushing’s disease, primary aldosteronism, pheochromocytoma, and congenital adrenal hyperplasia. Each pathology chapter delves into etiopathogenic aspects, clinical evidence, and therapeutic recommendations. This publication caters equally to endocrinologists and professionals from various medical disciplines, serving as a valuable resource for information on the adrenal gland from both a physiological and pathological perspective.
Islamic Finance
This book provides an overview of the practice of Islamic finance and the historical roots that define its modes of operation. The focus of the book is analytical and forward-looking. It shows that Islamic finance exists mainly as a form of rent-seeking legal-arbitrage. In every aspect of finance - from personal loans to investment banking, and from market structure to corporate governance - Islamic finance aims to replicate in Islamic forms the substantive functions of contemporary financial instruments, markets, and institutions. By attempting to replicate the substance of contemporary financial practice using pre-modern contract forms, Islamic finance has arguably failed to serve the objectives of Islamic law. This book proposes refocusing Islamic finance on substance rather than form. This approach would entail abandoning the paradigm of 'Islamization' of every financial practice. It would also entail reorienting the brand-name of Islamic finance to emphasize issues of community banking, micro-finance, and socially responsible investment.
Chronic Autoimmune Epithelitis
Epithelial tissue does not spring to mind as an obvious source of autoimmune phenomena. Yet, genetic predisposition and influence of various environmental and epigenetic factors may lead to epithelium becoming a springboard for the development of autoimmune diseases, such as Sjögren’s syndrome, primary biliary cholangitis, autoimmune pancreatitis, or IgG4-related diseases. This book is intended as an introduction to the problem of “autoimmune epithelitis” and diseases closely related to the immune disturbances of the epithelium, with special emphasis on those affecting exocrine glands. Both theoretical and practical knowledge, presented by authors from a wide range of medical specialties, should be of help for medical professionals who have to deal with this difficult problem in their daily practice.
Fish Welfare
Fish have the same stress response and powers of nociception as mammals. Their behavioural responses to a variety of situations suggest a considerable ability for higher level neural processing – a level of consciousness equivalent perhaps to that attributed to mammals. Each chapter of this book has been written by specialists in their field. The subject matter is wide ranging and covers in detail concepts of animal welfare in addition to more specific aspects of fish welfare. Philosophical concepts of welfare are discussed along with more practical areas of fish welfare encompassing all husbandry and management activities that have a potential to affect the welfare of the fish in our care. This book is an essential purchase for fish veterinarians, fish farmers, fish biologists and those involved in the aquaculture industry and its regulation.
Alkenes
Alkenes, which have carbon-carbon double bonds, are chemicals and energy sources that play an important role in human life, including economics and the environment. This book examines the production and synthesis of alkenes, olefins, and polyolefins, as well as environmental issues faced during industrial production of these hydrocarbons. It also discusses eco-friendly and green separation techniques.
