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Systems immunology to advance vaccine development
Vaccines are one of the most effective methods for preventing and minimizing the spread of infectious diseases and are thus considered a cornerstone of public health. However, despite the successful development of vaccines that induce a protective immune response, most of the vaccines still being administered today have been developed empirically, with limited immunological insight. A deeper understanding of the mechanisms leading to a protective immune response is greatly needed to develop new vaccines for antigenically variable pathogens, such as the influenza virus, and to control infectious disease outbreaks, such as COVID-19. This includes studying the individual components involved, as well as the complex interactions between them.
Reassessing Twenty Years of Vaccine Development Against Tuberculosis
Tuberculosis (TB) remains the prime bacterial infection worldwide with 10.4 million infections and a death toll of 1.7 million people in 2016 according to WHO statistics. Tuberculosis is caused by members of the Mycobacterium tuberculosis complex, facultative intracellular bacteria able to thrive within otherwise potent innate defense cells, the macrophages. In a world of increasing numbers of infections with drug resistant M. tuberculosis strains, the daunting race between developing new therapeutics and emerging resistant strains will hardly produce a winner. This cycle can only be broken by enhancing population wide immune control through a better vaccine as the only one currently in use,...
Current Challenges in Vaccinology
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).
Immunopotentiators in Modern Vaccines
Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. - Contributions from leading international authorities in the field - Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system - Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator
Advances in Virus Research
The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field. The series of eclectic volumes are valuable resources to virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers. Volume 89 features articles on topics including plant-based vaccines, transmission of arthropod-borne viruses by mosquitoes, arboviruses in domestic and wild animals, and more. - Contributions from leading authorities - Comprehensive reviews for general and specialist use - First and longest-running review series in virology
Encyclopedia of Immunobiology
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
