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Worldwide more than one million babies die annually from perinatal asphyxia and its associated complications such as neonatal encephalopathy - one of the major causes of cerebral palsy and cognitive deficiencies in children aside from prematurity. Cooling the head - or the entire body - minimizes neuronal death, enabling the neonatal brain to be 'rescued' thus greatly improving developmental outcomes. Hypothermic neural rescue therapy has revolutionized the treatment of this condition and is a major recent achievement in neonatal medicine. This landmark book provides a brief scientific underpinning of hypothermic neural rescue therapy and lays out the evidence base for good practice. Internationally recognized authorities give practical advice, drawn from personal experience, on how to deliver hypothermia in the neonatal intensive care unit. A valuable addition to any neonatal unit, this is essential reading for neonatologists, neonatal nurses and paediatric neurologists.
In this issue of Clinics in Perinatology, guest editor Dr. Lina Chalak brings her considerable expertise to the topic of Perinatal Asphyxia: Moving the Needle. Top experts discuss current clinical information on perinatal asphyxia, giving perinatologists they guidance they need to improve outcomes in newborns, while looking at results from clinical trials, neuroimaging biomarkers, and low-resource settings. - Contains 15 practice-oriented topics including the role of a maternal-placental-fetal triad; treating seizures and improving newborn outcomes; advances in neuroimaging biomarkers and scoring; moving the needle in low-resource settings: is hypothermia a friend or foe?; ethical and medicolegal perspectives on cooling: where to draw the line?; and more. - Provides in-depth clinical reviews of perinatal asphyxia, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.
Now in its third edition, this is a comprehensive survey of fetal and neonatal brain injury arising from hypoxia, ischemia or other causes. The volume spans a broad range of areas from epidemiology and pathogenesis, through to clinical manifestations and obstetric care, and then on to diagnosis, long-term outcomes, and medico-legal aspects. An important theme running throughout is to highlight scientific and clinical advances that have a role to play in minimising risk, improving clinical care and outcomes.
Written by leading global experts in the field, Principles of Neonatology provides those on the NICU team with clinically focused, evidence-based guidance in an easy-to-access format. Chapters cover the key topics of greatest and most frequent concern to clinicians treating newborns, delivering current, data-driven management and treatment advice in a single source relevant to the seasoned practitioner, fellow, or trainee. - A highly templated format makes it easy to find exactly the information you need. - Lavishly illustrated with photos, radiographs, drawings, and charts and graphs that clarify key concepts in a helpful and accessible way. - Evidence-based focus ensures that only the most...
Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today's busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application. - Offers definitive guidance on...
The Guest Editors have compiled a comprehensive issue that includes both disorders of endocrinology as well as diabetes. Authors have addressed the following clinical topics: disorders of menstruation, thyroid function; gender dysphoria; hypoglycemia in the nondiabetic child; preventing DKA; short- and long-term outcomes in diabetes, and whole genome sequencing in endocrinology. These topics represent the current knowedge in the field, and pediatricians will have the most updated clinical information as they evaluate and treat children with diabetes or endocrinology disorders.
**Selected for Doody's Core Titles® 2024 in Neurology**Stay up to date with today's latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology, with the definitive text in the field. Volpe's Neurology of the Newborn, 7th Edition, shares the knowledge and expertise of world authority Dr. Joseph Volpe, who, along with Dr. Terrie E. Inder of Children's Hospital of Orange County and other distinguished editors, brings a wealth of insight to this classic text. Known for its clear, engaging writing style, vibrant, full-color illustrations, and authoritative information throughout, this reference is an indispen...
Preterm birth affects over 15 million newborns worldwide each year and is the main contributor of neonatal mortality and morbidity. While neonatal survival following preterm birth continues to improve, this has not been matched by a decline in neurological outcome. There is still a high prevalence of motor problems, executive dysfunction, and cognitive impairment in infants born preterm. Improved neuroimaging has helped to describe different types of neonatal brain injuries in this population and has given a better understanding of underlying pathogenesis. However, therapies are still lacking and there is a great need to find novel strategies to improve injury and functional outcome.