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Science
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Antigenic Variation
The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.Comprehensive coverage of antigenic variation from viruses to parasitesDiscussions devoted to molecular mechanisms of host evasionDetailed descriptions of host/pathogen interactions
Immunity to Malaria and Vaccine Strategies
Malaria, caused by infection with protozoan parasites belonging to the genus Plasmodium, is a highly prevalent and lethal infectious disease, responsible for 435,000 deaths in 2017. Optimism that malaria was gradually being controlled and eliminated has been tempered by recent evidence that malaria control measures are beginning to stall and that Plasmodium parasites are developing resistance to front-line anti-malarial drugs. An important milestone has been the recent development of a malaria vaccine (Mosquirix) for use in humans, the very first against a parasitic infection. Unfortunately, this vaccine has modest and short-lived efficacy, with vaccinated individuals possibly being at incre...
The Backstreets of Purgatory
Finn Garvie’s life is one spectacular mess. He spends most of his time fannying around a makeshift Glasgow studio, failing to paint his degree portfolio, while his girlfriend Lizzi treats him like one of her psychology patients, and his best friend Rob is convinced that the tattoos he designs are the height of artistic achievement. To top it all, Finn is worried that some stinking bastard is hanging around, spying on him, laughing at his cock-ups and eating his leftover curry. Fortunately, he has plenty of techniques to distract him – tackling the church hall renovations with the help of his alcoholic neighbour; pining after Kassia, the splendidly stroppy au-pair; and re-reading that boo...
Sexology
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Structure
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