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Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have p...
More than a year and a half has passed since Alys, Claudia, Jane and Charles helped to free the great sorceress, Morgana Shee, from imprisonment and close the passage between the Stillworld and the Wildworld. But when an earthquake hits California and continues to shake with lingering aftershocks, the Hodges-Bradley children begin to suspect this was no ordinary quake, and that the passage seal between the worlds may no longer be stable. With their parents overseas and Morgana travelling north to find the epicentre of the quake the children are left on their own. But peril lurks around every corner, and strange happenings in their home town force them on journey that will test their skills to the very limit. It seems that Morgana's archrival, Thia Pendriel, has stolen the Forgotten Gem, the Heart of Valour, and is waiting to spring her trap…
When Claudia Hodges-Bradley meets a fox, she knows it will be an extraordinary day. Not just any fox, this vixen is the magical familiar of the sorceress Morgana Shee. For years Morgana has guarded the solitary gate between Earth and the Wildworld, a shimmering parallel universe where legends still live. She alone holds the secret of the mirrors that serve as the last passage to enchantment. But Morgana has been betrayed and imprisoned in Wildworld, and the fox is determined to recruit the Hodges-Bradley kids for the rescue mission. Armed only with courage and determination, Alys, Charles, Janie and Claudia must save Morgana before the Winter Solstice when the evil sorcerer Cadal Forge plans to escape Wildworld and conquer Earth. And with December 21 only two weeks away, there is no time to lose….
As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing hum...
This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).
Spontaneous Pathology of the Laboratory Non-human Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research.Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. - Contains color illustrations that depict the most common lesions to augment descriptions - Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) - Provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. - Presents updated chapters on systems toxicologic pathology, including new chapter on olfactory - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions to highlight difficult concepts with clear illustrations