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Brain Organoids: Modeling in Neuroscience
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Transient Receptor Potential Canonical Channels and Brain Diseases
This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians...
The Neuroscience of Autism Spectrum Disorders
Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the ...
Programmed Cells from Basic Neuroscience to Therapy
The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. De...
Working with Stem Cells
The content covered encompass not only the theoretic and methodological aspects for culturing human pluripotent stem cells, but also the establishment of induced pluripotent stem cells and their differentiation into specific cellular subtypes. This book has the most updated methods and technologies in an accessible and clear language, presenting protocols developed and optimized by researchers that use them every day. Stem cell research is a growing field that offers the potential to comprehend mechanisms of neural development and tissue regeneration and maintenance as well as the development-related human diseases and the establishment of novel therapies. Questions of basic biology can also be exploited by this cutting-edge approach.
Cancer Research
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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an exten...
Estudos avançados
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Wie wir die Welt verändern
Bestseller-Autor Stefan Klein nimmt uns mit auf eine spannende Reise durch die Geschichte des schöpferischen Denkens. Von den Innovationen der Steinzeit wie Malerei über die Erfindung der Schrift bis hin zu den Leistungen der Computer von morgen zeigt Stefan Klein anschaulich und unterhaltsam, wie der Geist immer wieder neu die Welt verändert hat. Wir begegnen Neandertalern und Steve Jobs, Leonardo da Vinci und Ada Lovelace, Archimedes und AlphaZero. Dabei wird deutlich: Innovation und Fortschritt verdanken wir nicht den Einfällen einsamer Genies – sie entwickeln sich im geistigen Austausch. Denn Kreativität, Phantasie und Innovation sind keine individuellen Talente, sondern entstehen zwischen den Menschen. Wie wurde unsere Welt die, in der wir leben? Wie wurden wir, was wir sind? Und wie geht es weiter? Jede Veränderung beginnt mit einer neuen Idee! Packend erzählt der renommierte Wissenschaftsautor von der Macht der Gemeinschaft, der Zukunft des Denkens und den unbegrenzten Möglichkeiten unserer Kreativität.
O reizinho autista
Todas as crianças apresentam comportamentos inadequados no dia a dia. Ensinar condutas adequadas é importante para o bom desenvolvimento. O manejo dessas situações com crianças no espectro autista é diferente, pois existem atrasos na comunicação social, verbal e não-verbal, dificuldade na compreensão dos efeitos que seus comportamentos causam nas outras pessoas, dificuldade em habilidades sociais e rigidez comportamental. Os sintomas do autismo dificultam ainda mais a possibilidade de compreensão e negociação em situações difíceis. O livro O Reizinho Autista: Guia para lidar com comportamentos difíceis, escrito pelo Dr. Gustavo Teixeira e pela Dra. Mayra Gaiato, ambos especi...
