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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.
Cardiometabolic diseases and inflammatory responses
Cardiometabolic diseases are driven by both metabolic disorders (obesity, insulin resistance, non-alcoholic fatty liver diseases, and atherosclerosis) and chronic inflammation (e.g. in diabetes, hypertension and autoimmune diseases), leading to coronary artery disease and heart failure. The perivascular or pericardiac adipose tissue expansion affecting both the systemic and tissue compartment is favored in cardiometabolic disease development. This adipose tissue is a major component of the cardiovascular system that is dysregulated during the consumption of fat-enriched diets. Additionally, fat-enriched diets profoundly impact the response of immune cells in specialized tissues, as well as the activation and differentiation of tissue-resident progenitors. This results in both dysfunction and remodeling that is not limited to tissues, but also to cell activity. The fate of cardiovascular diseases associated with metabolic disorders promotes the imbalance in pro- and anti-inflammatory environments.
AHA Scientific Sessions 2019 - Final Program
The American Heart Association’s Scientific Sessions 2019 is bringing big science, big technology, and big networking opportunities to Philadelphia, Pennsylvania this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
The Girl You Left Behind
France, 1916. Sophie Lefevre must protect her whilst her husband fights at the front, even when she is forced to serve the German officers who descend on her hotel each evening. From the moment the Kommandant sets eyes on Sophie's portrait a dangerous obsession is born. Sophie must soon make a dark and terrible decision... Almost a century later Sophie's portrait hangs in Liv Halston's home. A chance encounter reveals the painting's troubled history, a history about to resurface and turn Liv's life upside down. . .
Joint Volumes of Papers Presented to the Legislative Council and Legislative Assembly
Includes various departmental reports and reports of commissions. Cf. Gregory. Serial publications of foreign governments, 1815-1931.
Jamais je ne te pardonnerai
Le combat déchirant d'une fille contre la perversité de son père. Le combat déchirant d'une fille contre la perversité de son père. Sandra a huit ans lorsque Moira, une de ses amies, disparaît. On ne la retrouvera jamais. Dans sa petite communauté de la banlieue de Glasgow, c'est un véritable choc. Trente-cinq ans plus tard, Sandra apprend de la bouche de son père qu'il n'est pas étranger à l'affaire. Elle comprend alors que le comportement de ce dernier envers ses cousines, ses amies et elle-même n'a jamais été normal. Elle s'aperçoit que tous, de ses voisins à sa famille en passant par la police, savait que son père était un pédophile. Sandra s'engage dans une lutte sans merci pour prouver sa culpabilité et le faire condamner.
The British Imperial Calendar and Civil Service List ... Or
Includes: The British or imperial almanac, A Companion to the British imperial calendar, and An Alphabetical index to the imperial calendar (title varies),
Municipal Year Book
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