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New Insights Into Prostate Cancer: New Biomarkers, Molecular Mechanisms, and Therapeutic Approaches
Prostate cancer is the second most common cancer in men, and prognosis varies with age, ethnicity, genetic background, and stage of progression. Disease progression that has been observed in a substantial proportion of patients despite androgen ablation, can arise from many factors, such as the presence of cells that are resistant de novo or acquire resistance induced by androgen-deprivation therapy (ADT) or androgen receptor antagonists.
Continued Learning of Tissue-specific Immunity from the Immuno-Pathological Spectrum of Leprosy
Leprosy is one of the oldest recorded debilitating diseases affecting mankind, the immunopathology of which is characterized by fluctuating granulomatous inflammation that targets mainly skin and peripheral nerve. The disease is caused by infection with Mycobacterium leprae, a slow growing obligatory intracellular and non-cultivatable organism. The disease is manifested with diverse pathology due to varied immune (both innate and adaptive) responses of the hosts as a result of cognate interaction with the organism. Of note, leprosy can be regarded as a unique model to elucidate the complexity of host immunity at both skin and systemic levels.
Recent Advances in Prolactin Research
Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL ...
Neurocovid
El Departamento de Neurociencias del Centro Universitario de Ciencias de la Salud presenta esta obra científico-académica que estudia los efectos de la enfermedad covid-19 sobre el sistema nervioso (afecciones también conocidas como "neurocovid"), a fin de comprender, actualizar y divulgar oportunamente el conocimiento sobre esta afectación, sus complicaciones, secuelas y efectos secundarios a largo plazo por la acción del virus SARS-CoV-2 y el desarrollo de la enfermedad. Tiene, además, el propósito de motivar esfuerzos de investigación para abordar, prever y reducir el impacto funcional de la infección, particularmente en los aspectos neuropsicológico y neuropsiquiátrico de los pacientes.
Immunopathology of Chronic Bacterial and Viral Diseases Prevalent in Latin America
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). Prof. Leopoldo Santos-Argumedo is the President of the Latin American Association of Immunology (ALAI); Prof. Rosana Pelayo is the President of Sociedad Mexicana De Inmunología (SMI) and Prof. Luis García is a former ALAI President.
Dos Sonhos Nascem Os Mitos
“Cacilda Becker: Dos Sonhos Nascem os Mitos” é um precioso documentário, escrito por um professor e jornalista que há mais de trinta anos se dedica a pesquisa e ao resgate da vida desta pirassununguense maravilhosa que foi Cacilda Becker. Com uma elegância de estilo, rigorosamente disciplinada pelo bom senso, Israel nos mostra que realmente dos sonhos daquela menina franzina, de voz rouca e trejeitos interioranos, desengonçada, surgiria este mito chamado Cacilda Becker. Cacilda já era merecedora de um livro que realmente expresse sua simplicidade e seriedade pela arte que desenvolvia. Este livro vem suprir esta lacuna e nada melhor que um escritor que, igualmente a Cacilda, nasceu em Pirassununga. Israel possui a majestade da energia do autor porque enriquece, com seu esforço informativo honesto e interessado em apenas divulgar a cultura, fazendo com que o mito Cacilda Becker sirva de exemplo as gerações vindouras, não apenas pelo seu esforço em prol da arte que realizava, mas principalmente por seus sonhos e suas lutas, arrebatando problemas e mais problemas, transformando os limões que lhe eram dados em deliciosas limonadas.
Cochrane Handbook for Systematic Reviews of Interventions
Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention revie...
Francisco Suárez: Metaphysics, Politics And Ethics
O presente volume publica as Atas do Iº Encontro Internacional “Pensar o Barroco em Portugal” (26-28 de Junho de 2017), que se ocupou do pensamento metafísico, ético e político de Francisco Suárez. Contando com a colaboração de alguns dos maiores especialistas internacionais na obra e no pensamento deste famoso professor da Universidade de Coimbra no século XVII, este volume celebra os 400 anos da sua morte e assinala a produtividade do seu legado filosófico-teológico.
