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This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery
The Desclergues of la Villa Ducal de Montblanc (2nd edition) is a comprehensive ancestral chronicle, meticulously tracing the Desclergues family lineage from the Greek era through the Villa Ducal de Montblanc in Tarragona to the present in Belgium. This omnibus edition compiles the entire acclaimed series, offering an exhaustive account of the Desclergues of Montblanc alongside the author's other ancestral lines, including de Patin, de Patin de Langemark, Lesage, Benoit, Den Dauw, 't Kint, Surmont, de Croock, Ardan, Lammens, Decaestecker, and de Silva of Uduwara in Sri Lanka. This scholarly work is enriched by a comprehensive DNA analysis, providing genetic depth to the historical narrative....
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This book provides readers with a thorough review on cervical cancer, treatment guidelines and emerging therapies available for the disease. It reviews the epidemiology clinical features, diagnosis, and medical management of cervical cancer. Given the increasing need for preventive strategies, treatment optimization with collaborative and integrative work, this book improves the actual and integral knowledge in this neoplasm. Given the high prevalence of this disease in Latin America, this is an important text for clinicians in this region. This book outlines the state of the art in cervical cancer treatments and is an indispensable companion for oncologists, gynecologists, surgeons and medical students.
This text addresses the current levels of evidence for management of a variety of critical parameters after severe traumatic brain injury (TBI), as well as providing the reader with practical approaches to care based upon existing evidence. A broad range of topics is included, ranging from specific critical care approaches to TBI to broader questions of prognostication and philosophies of treatment. Critical care topics include, for example: the type, timing, and safety of DVT prophylaxis; the choice of sedative agents in brain-injured patients; the practical application of multimodality neuromonitoring for prevention of secondary insults and injury; and the optimal treatment of dysautonomia...