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This Research Topic is the second volume of the Community Series, Liver Fibrosis and MAFLD: from Molecular Aspects to Novel Pharmacological Strategies. Please find the first Edition here. Metabolic disorders, such as obesity and type 2 diabetes mellitus, represent a critical health problem. This is mainly due to the economic cost of health services supporting the treatment for these patients of both primary and secondary disorder effects. Fatty liver damage associated with metabolic dysfunction is currently called Metabolic Associated Fatty Liver Disease (MAFLD), a new concept proposed in 2020, which affects a quarter of the population worldwide and is characterized by liver fat accumulation and all the repercussions that this may bring, such as inflammation, fibrosis, cirrhosis and in some cases, hepatocellular carcinoma.
The Human Hepatitis D virus (HDV) is one of the smallest human RNA viruses (22 nm), characterized by the peculiarity to require Hepatitis B virus (HBV) for its replication. Indeed, HDV utilizes HBV surface glycoprotein (HBsAg) for viral entry, assembly and release, implying the need for a intrahepatic transcriptionally active HBV to ensure HDV replication. Chronic HBV/HDV coinfection is associated with a high risk of developing liver cirrhosis and hepatocellular carcinoma within 5–10 years, resulting in high fatality rate. Recent estimates suggest that 9-60 million individuals may be infected with HDV worldwide. However, these fluctuating estimates highlight a huge uncertainty about the real prevalence of HDV infection, mostly related to the lack of robust data on large populations of HBsAg positive patients undergoing HDV screening. This highlights the need of accurate screening programs that finely trace the circulation of HDV.
Recent Advances in Nanomedicines Mediated Wound Healing presents an overview of various nanotechnology-based drug delivery systems explored widely for wound healing. The book provides a comprehensive review of thriving strategies used for wound healing and thoroughly describes the most recent developments in emerging modern drug delivery systems with a focus on nanotechnology. It serves as a complete package for a holistic understanding of molecular pathways, conventional therapy, and novel nanocarrier-mediated drug delivery for wound healing while also exploring advanced strategies like siRNA and aptamer mediated approaches and nanomedicines to treat diabetic and full thickness wounds.This ...
This Research Topic is part of a series with: Herbal Medicines for Gastrointestinal and Hepatic Diseases - Novel Pharmacological and Toxicological approaches, Volume II Ethnopharmacology deals with the exchange of knowledge about people's use of herbal medicines and their pharmacological effects. The information related to therapeutic agents of plant origin and their toxic effects was preserved by oral tradition as well as recorded in materia medica. Many drugs that are now available on the market have been developed from this valuable information. Today, scientists that specialize in medicinal chemistry use these existing herbal drugs to develop and produce more therapeutically active agent...
The ICTM Study Group on Music Archaeology was founded in the early 1980s by Ellen Hickmann, John Blacking, Mantle Hood and Cajsa S. Lund. This is the first volume of the new anthology series published by the study group, turning to the topic of music and religion in past cultures. Each volume of the series is composed of concise case studies, bringing together the world's foremost researchers on a particular subject, reflecting the wide scope of music-archaeological research world-wide. The series draws in perspectives from a range of different disciplines, including newly emerging fields such as archaeoacoustics, but particularly encouraging both music-archaeological and ethnomusicological perspectives.
What is land? A resource to be exploited? A commodity to be traded? A home to cherish? In Guatemala, a country still reeling from thirty-six years of US-backed state repression and genocides, dominant Canadian mining interests cash in on the transformation of land into “property,” while those responsible act with near-total impunity. Editors Catherine Nolin and Grahame Russell draw on over thirty years of community-based research and direct community support work in Guatemala to expose the ruthless state machinery that benefits the Canadian mining industry—a staggeringly profitable juggernaut of exploitation, sanctioned and supported every step of the way by the Canadian government. Th...
Phenolic compounds, one of the most widely distributed groups of secondary metabolites in plants, have received a lot of attention in the last few years since the consumption of vegetables and beverages with a high level of such compounds may reduce risks of the development of several diseases. This is partially due to their antioxidant power since other interactions with cell functions have been discovered. What’s more, phenolic compounds are involved in many functions in plants, such as sensorial properties, structure, pollination, resistance to pests and predators, germination, processes of seed, development, and reproduction. Phenolic compounds can be classified in different ways, rang...
A growing awareness of the relationship between diet and health has led to an increasing demand for food products that support health beyond simply providing basic nutrition. Digestive health is the largest segment of the burgeoning functional food market worldwide. Incorporation of bioactive oligosaccharides into foods can yield health benefits in the gastrointestinal tract and other parts of the body that are linked via the immune system. Because oligosaccharides can be added to a wide variety of foodstuffs, there is much interest within the food industry in incorporating these functional ingredients into healthy food products. Moreover, other areas such as pharmaceuticals, bioenergy and e...
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