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The Role of Steroid Hormones and Growth Factors in Cancer
  • Language: en
  • Pages: 330
Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment
  • Language: en
  • Pages: 499

Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment

Gastrointestinal (GI) cancer, the group of cancers that affect the gastrointestinal tract and other organs that are contained within the digestive system, including the esophagus, pancreas, stomach, colon, rectum, anus, liver, biliary system and small intestine, is the most common malignant diseases with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Diverse subtypes of GI cancer impressively exhibit similar characteristics like high frequency oncogenic mutation burden, early metastatic potency, chemo-resistance and immunotherapeutic tolerance indicating a possible unique tumorigenic mechanism.

Vasculogenesis and Angiogenesis
  • Language: en
  • Pages: 242

Vasculogenesis and Angiogenesis

Vasculogenesis is the process of new blood vessel formation during embryonic development of the cardiovascular system. This is followed by formation of a vascular tree and finally the cardiovascular system with the myriad of blood vessels that nourish all tissues and organs. Angiogenesis, on the other hand is the process by which new blood vessels take shape from existing blood vessels by "sprouting" of endothelial cells thus expanding the vascular tree. Both scenarios are based on activation, migration, proliferation and maturation of unique precursor cells. The study of blood vessel formation is an essential component of embryonic development, congenital malformations, degenerative disease...

The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
  • Language: en
  • Pages: 130

The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade t...

Surgical Management of Head and Neck Pathologies
  • Language: en
  • Pages: 192

Surgical Management of Head and Neck Pathologies

The book is an introduction to concepts in head and neck surgical pathology that are both novel and proven. Chapters discuss the various anatomic, reconstructive, and esthetic considerations that are often unique to surgeries of the head, face, and neck. International cooperation was made to ensure that a wide range of perspectives is presented in this volume.

Cancer Ecosystems
  • Language: en
  • Pages: 226

Cancer Ecosystems

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Establishment of marker models for molecular typing of renal cell carcinoma
  • Language: en
  • Pages: 233
Recent Advances in Angiogenesis and Antiangiogenesis
  • Language: en
  • Pages: 143

Recent Advances in Angiogenesis and Antiangiogenesis

"The book presents recent advances in the field of angiogenesis and antiangiogenesis. Starting with the hypothesis of Judah Folkman that tumor growth is angiogenesis dependent, this area of research now has a solid scientific foundation. Tumor growth, meta"