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Quantum Medicinal Chemistry
  • Language: en
  • Pages: 294

Quantum Medicinal Chemistry

Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms have made quantum chemistry a valuable tool in the search for active substances. Written by a team of leading international quantum chemists, this book is aimed at both beginners as well as experienced users of quantum chemical methods. All commonly used quantum chemical methods are treated here, including Density Functional Theory, quantum and molecular mechanical approaches. Numerous examples illustrate the use of these methods for dealing with problems in pharmaceutical practice, whether the study of inhibitor binding, identifying the surface load of active substances or deriving molecular descriptors using quantum chemical tools. For anyone striving to stay ahead in this rapidly evolving field.

Experiments and Simulations: A Pas de Deux to Unravel Biological Function
  • Language: en
  • Pages: 182
Physico-chemical and Computational Approaches to Drug Discovery
  • Language: en
  • Pages: 443

Physico-chemical and Computational Approaches to Drug Discovery

This title covers a wide range of topics relevant to the development of drugs. It provides a comprehensive description of the major methodological strategies available for rational drug discovery.

Official Gazette of the United States Patent Office
  • Language: en
  • Pages: 2120

Official Gazette of the United States Patent Office

  • Type: Book
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  • Published: 1890
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  • Publisher: Unknown

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Official Gazette of the United States Patent Office
  • Language: en
  • Pages: 1028

Official Gazette of the United States Patent Office

  • Type: Book
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  • Published: 1886
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  • Publisher: Unknown

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Hemodiafiltration
  • Language: en
  • Pages: 228

Hemodiafiltration

Hemodiafiltration (HDF) for the treatment of end-stage renal disease patients is predominantly performed in European countries and in Japan, with some differences in technique such as rate of blood flow and dialysis fluid delivery systems. The main focus of this book is on the clinical importance of online HDF, the techniques of which have been re-evaluated with the introduction of super high-flux membrane dialyzers. After a brief introduction into the history of HDF, recent advances and clinical experiences of HDF are summarized, including water quality control for dialysis fluid, equipped system for safe use, clinical advantages, and theoretical aspects of HDF. Moreover, at the end of each chapter researchers and scientists discuss problems into which further research is needed. Clinicians and scientists involved in the treatment of end-stage renal disease patients will find this publication an essential source of information. Moreover, it may also serve as a textbook for those who are planning to start HDF in their clinics or who are studying blood purification therapies in medical schools, nursing schools and even in engineering schools related to medical technologies.

Modelling and Control of Dialysis Systems
  • Language: en
  • Pages: 785

Modelling and Control of Dialysis Systems

  • Type: Book
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  • Published: 2012-08-04
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  • Publisher: Springer

The book, to the best of the editor’s knowledge, is the first text of its kind that presents both the traditional and the modern aspects of ‘dialysis modeling and control’ in a clear, insightful and highly comprehensive writing style. It provides an in-depth analysis of the mathematical models and algorithms, and demonstrates their applications in real world problems of significant complexity. The material of this book can be useful to advanced undergraduate and graduate biomedical engineering students. This text provides an important focus on helping students understand how new concepts are related to and rely upon concepts previously presented. Also, researchers and practitioners in ...

Polypharmacology in Drug Discovery
  • Language: en
  • Pages: 542

Polypharmacology in Drug Discovery

An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Co...

Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design, Volume II
  • Language: en
  • Pages: 325