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The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus
Staphylococcus aureus S. aureus is a growing issue both within hospitals and community because of its virulence determinants and the continuing emergence of new strains resistant to antimicrobiotics. In this book, we present the state of the art of S. aureus virulence mechanisms and antibiotic-resistance profiles, providing an unprecedented and comprehensive collection of up-to-date research about the evolution, dissemination, and mechanisms of different staphylococcal antimicrobial resistance patterns alongside bacterial virulence determinants and their impact in the medical field. We include several review chapters to allow readers to better understand the mechanisms of methicillin resistance, glycopeptide resistance, and horizontal gene transfer and the effects of alterations in S. aureus membranes and cell walls on drug resistance. In addition, we include chapters dedicated to unveiling S. aureus pathogenicity with the most current research available on S. aureus exfoliative toxins, enterotoxins, surface proteins, biofilm, and defensive responses of S. aureus to antibiotic treatment.
New Insights in Leprosy (Hansen's Disease)
Leprosy (or Hansen’s disease) is a chronic infectious granulomatous disease caused by Mycobacterium leprae and Mycobacterium lepromatosis that affects predominantly the skin and peripheral nerves. Leprosy is one of the oldest known illnesses of mankind; however, it is still one of the most neglected diseases worldwide, impacting more than 120 countries, mainly in underdeveloped settings. Early diagnosis and treatment are crucial for reducing the burden of this disease and avoiding long-term irreversible consequences such as deformities and mutilations. Thus, the World Health Organization has focused its efforts on preventive programs as well as the search for easy-to-handle diagnosis tools and the implementation of new strategies to improve the therapeutic options available.
Improving Complex Systems Today
As the main theme of Improving Complex Systems Today implies, this book is intended to provide readers with a new perspective on concurrent engineering from the standpoint of systems engineering. It can serve as a versatile tool to help readers to navigate the ever-changing state of this particular field. The primary focus of concurrent engineering was, at first, on bringing downstream information as far upstream as possible by introducing parallel processing in order to reduce time to market and to prevent errors at a later stage which would sometimes cause irrevocable damage. Up to now, numerous new concepts, methodologies and tools have been developed, but over concurrent engineering’s 20-year history the situation has changed extensively. Now, industry has to work in the global marketplace and to cope with diversifying requirements and increasing complexities. Such globalization and diversification necessitate collaboration across different fields and across national boundaries. Thus, the new concurrent engineering calls for a systems approach to gain global market competitiveness. Improving Complex Systems Today provides a new insight into concurrent engineering today.
Dengue Fever in a One Health Perspective
Dengue Fever in a One Health Perspective underlines important aspects of dengue virus, the most prevalent and life-threatening arbovirus in the world. Over three sections, chapters cover such topics as biological and environmental aspects, physiopathology, molecular biology, diagnosis, and control strategies. The first section provides knowledge on basic aspects of dengue virus biology and its emergence and re-emergence associated to environmental changes. The second section includes two chapters on dengue immunopathology, a drawback in disease control and vaccine development. Finally, the third section examines molecular biology tools employed in dengue virus immunopathogenesis studies, diagnosis, drug design, and in the use of vectors as sentinels in surveillance and vector biology studies.
Almanaque
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O Direito ao Trabalho da PCDI
O Direito Fundamental ao Trabalho da PCDI, uma análise do direito ao trabalho pela jurisprudência dos Tribunais do Trabalho é uma pesquisa sobre a evolução da norma trabalhista no ordenamento jurídico brasileiro e da atuação da Justiça do Trabalho para realização da mudança social adequada ao exercício da atividade laboral pela Pessoa com Deficiência Intelectual-PcDI. Visa ressaltar que essa concepção normativa do Direito do Trabalho é primordial para a evolução da sociedade e do mercado laboral brasileiro, como um movimento articulado entre agentes envolvidos no processo de estruturação das normas do trabalho para a solução das lides sobre a Lei de Cotas e a manutenção dos postos de trabalho para a Pessoa com Deficiência Intelectual, em momento anterior e posterior à vigência da Lei 13.146/2015, destacados pelas fundamentações da jurisprudência dos Tribunais do Trabalho na conformação e caracterização do DTPcDI como um subsistema necessário ao mercado de trabalho contemporâneo.
FIBA
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A educação e a contemporaneidade: formação de professores e discussões curriculares
O presente livro constitui-se de um compilado de estudos realizados por discentes do curso de Especialização em História, Ciências, Ensino e Sociedade da Universidade Federal do ABC (UFABC), em parceria com a Universidade Aberta do Brasil (UAB). Os estudos desenvolvidos exploraram temáticas que contribuem para uma formação docente mais ampla, possibilitando o acesso a um espaço de reflexão sobre a educação e sua historicidade, estratégias e metodologias, interdisciplinaridade e perspectivas críticas, tendo no espaço escolar seu enfoque principal. As pesquisas aqui apresentadas possuem em comum a análise de relevantes problemáticas da educação na contemporaneidade, destacand...
