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The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus
Staphylococcus aureus S. aureus is a growing issue both within hospitals and community because of its virulence determinants and the continuing emergence of new strains resistant to antimicrobiotics. In this book, we present the state of the art of S. aureus virulence mechanisms and antibiotic-resistance profiles, providing an unprecedented and comprehensive collection of up-to-date research about the evolution, dissemination, and mechanisms of different staphylococcal antimicrobial resistance patterns alongside bacterial virulence determinants and their impact in the medical field. We include several review chapters to allow readers to better understand the mechanisms of methicillin resistance, glycopeptide resistance, and horizontal gene transfer and the effects of alterations in S. aureus membranes and cell walls on drug resistance. In addition, we include chapters dedicated to unveiling S. aureus pathogenicity with the most current research available on S. aureus exfoliative toxins, enterotoxins, surface proteins, biofilm, and defensive responses of S. aureus to antibiotic treatment.
Improving Complex Systems Today
As the main theme of Improving Complex Systems Today implies, this book is intended to provide readers with a new perspective on concurrent engineering from the standpoint of systems engineering. It can serve as a versatile tool to help readers to navigate the ever-changing state of this particular field. The primary focus of concurrent engineering was, at first, on bringing downstream information as far upstream as possible by introducing parallel processing in order to reduce time to market and to prevent errors at a later stage which would sometimes cause irrevocable damage. Up to now, numerous new concepts, methodologies and tools have been developed, but over concurrent engineering’s 20-year history the situation has changed extensively. Now, industry has to work in the global marketplace and to cope with diversifying requirements and increasing complexities. Such globalization and diversification necessitate collaboration across different fields and across national boundaries. Thus, the new concurrent engineering calls for a systems approach to gain global market competitiveness. Improving Complex Systems Today provides a new insight into concurrent engineering today.
Dengue Fever in a One Health Perspective
Dengue Fever in a One Health Perspective underlines important aspects of dengue virus, the most prevalent and life-threatening arbovirus in the world. Over three sections, chapters cover such topics as biological and environmental aspects, physiopathology, molecular biology, diagnosis, and control strategies. The first section provides knowledge on basic aspects of dengue virus biology and its emergence and re-emergence associated to environmental changes. The second section includes two chapters on dengue immunopathology, a drawback in disease control and vaccine development. Finally, the third section examines molecular biology tools employed in dengue virus immunopathogenesis studies, diagnosis, drug design, and in the use of vectors as sentinels in surveillance and vector biology studies.
New Insights in Leprosy (Hansen's Disease)
Leprosy (or Hansen’s disease) is a chronic infectious granulomatous disease caused by Mycobacterium leprae and Mycobacterium lepromatosis that affects predominantly the skin and peripheral nerves. Leprosy is one of the oldest known illnesses of mankind; however, it is still one of the most neglected diseases worldwide, impacting more than 120 countries, mainly in underdeveloped settings. Early diagnosis and treatment are crucial for reducing the burden of this disease and avoiding long-term irreversible consequences such as deformities and mutilations. Thus, the World Health Organization has focused its efforts on preventive programs as well as the search for easy-to-handle diagnosis tools and the implementation of new strategies to improve the therapeutic options available.
FIBA
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Diplomatic List
Directory of foreign diplomatic officers in Washington.
The Materiality of Terracotta Sculpture in Early Modern Europe
Through meticulously researched case studies, this book explores the materiality of terracotta sculpture in early modern Europe. Chapters present a broad geographical perspective showcasing examples of modelling, firing, painting, and gilding of clay in Portugal, Spain, Italy, Germany, and the Netherlands. The volume considers known artworks by celebrated artists, such as Luca della Robbia, Andrea del Verrocchio, Filipe Hodart, or Hans Reichle, in parallel with several lesser-studied terracotta sculptures and tin-glazed earthenware made by anonymous artisans. This book challenges arbitrary distinctions into the fine art and the applied arts, that obscured the image of artistic production in the early modern world. The centrality of clay in the creative processes of artists working with two- and three-dimensional artefacts comes to the fore. The role of terracotta figures in religious practices, as well as processes of material substitutions or mimesis, confirm the medium’s significance for European visual and material culture in general. This book will be of interest to scholars working in art history, Renaissance studies, and material culture.
