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Purinergic Receptors and their Modulators
This book overviews purinergic receptors that are playing key roles in human and pathophysiological processes. The book elaborates on how selective P1 and P2 modulators have been developed as therapeutics for a variety of diseases. It also provides an overview of current perspectives in the design of purinergic receptor modulators and future challenges such as the availability of selective ligands for all receptor subtypes. Divided into 12 chapters, this comprehensive volume also offers a multidisciplinary perspective on the historical evolution, starting with a chapter devoted to the roots and early discoveries of adenosine and its receptors, followed by a twenty-year retrospective on the s...
A Bouquet of Barbed Wire
Peter Manson's apparently successful life is turned upside down when his beloved teenage daughter Prue reveals she's pregnant by her teacher, Gavin Sorenson. The very heart of the family is threatened as Peter has an intuitive sense that Gavin is on a personal quest for revenge. As Peter becomes consumed by anxiety for his daughter, hatred of his son in law and lust for his secretary, his relationship with his wife, Cassie, becomes increasingly distant. With Peter's marriage at breaking point and facing financial ruin, it's only a matter of time before secrets from the past return to haunt their lives. Famously controversial, the 1970s TV adaptation of A Bouquet of Barbed Wire was watched by 26 million people. ITV's new version is written by Guy Andrews (Lost in Austen, Prime Suspect) and will star Trevor Eve, Hermione Norris and Imogen Poots.
The Vanishing Point
A dazzling and spellbinding debut about a mysterious painting, the secrets it keeps, and the two women connected across centuries by a quest to discover the truth – for readers of Geraldine Brooks, Tracy Chevalier and Maggie O'Farrell. London, 1991: Alex Johns, an art intern at the Courtauld, believes a hidden secret lies within Diego Velázquez’s Las Meninas – one of the most written about paintings of all time. Her mother died in mysterious circumstances while trying to uncover its secrets and Alex is troubled by memories of her own encounter as a child with the girl in the painting – the Infanta Margarita – who continues to haunt her. Alex must take up her mother’s work and fi...
The Enlightenment of Nina Findlay
There were once two brothers, tall dark and handsome brothers who loved each other with absolute love, and who as boys met a girl called Nina, as fair as they were dark, whose pale hair and pale blue eyes marked her as a fairy creature.
I'm Sorry... Love Anne
Anne is a single, 24-year-old paralegal who is haunted by an inscription she finds in a book written by a woman with the same name. Impelled to discover the tale behind the mysteriously sad words she unearths a decades old murder, power gone awry and a story of broken hearts. Reeling from her own recent failed relationship she finds herself charmed by a dashing young Englishman, with a dark secret, named Jarred whom she finds both intriguing and unsettling. A personal journal from the past leads her to the still very much alive and powerful killer. As her quest to uncover the truth consumes her life, she finds that she is facing decisions the magnitude of which she is only beginning to comprehend. I?m Sorry?.Love Anne, will take you on a ride from the past and the present, from one end of the earth to the other. It will make your heart race, break it in pieces, then remind you why you have one. It is not only a love story but is also a journey about what it means to truly be alive a
The Rose Notes
Charming, infuriating Dobie Kinnear, widower and manipulator extraordinaire, is battling to retain his wits, his authority, and his only daughter, Pearl. Pearl, a hostage to her ageing father's needs, fiercely resents her role as Dobie's unofficial housekeeper. The years are passing on their southern Riverina farm, and still her life lacks meaning or purpose. She loves the farm with a passion but, tending her rose garden, she dreams of escape. Then a stranger comes to Mamerbrook Farm bearing a secret from the past and a gift for the future. Along with an old scrapbook of roses, a hitchhiking angel, and an onion farmer with a knack for rescuing people, he will turn their world upside down . . . and change their lives forever. The Rose Notes has been listed for VCE Literature Studies 2008/9/10.
Addicts. Les drogues et nous
Bienvenue dans la société addictogène ! Alcool, tabac, cannabis, cocaïne, ecstasy, mais aussi écrans, jeux d'argent, porno en ligne : les addictions se sont démocratisées. La prolifération des produits psychotropes et des conduites addictives nous oblige à penser leur régulation. De plus en plus, le marché fournit des produits à moindres risques et des solutions techniques pour réduire leur nocivité. L'État, plutôt que de tout miser sur la répression, peut offrir un cadre propre à réduire les dommages socio-sanitaires. Ce double mouvement – expansion du marché et désengagement policier de l'État – renvoie le drogué dans le champ de la citoyenneté. Car les addicts sont des citoyens, comme vous et moi. Professeur à l'université de Lille, Christian Ben Lakhdar est l'un des meilleurs spécialistes de l'économie des drogues et des conduites addictives. Il est membre du Collège scientifique de l'Observatoire français des drogues et des toxicomanies.
Structural Biology in Drug Discovery
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major...
Lloyd's Register of Shipping 1916 Sailing Vessels
The Lloyd's Register of Shipping records the details of merchant vessels over 100 gross tonnes, which are self-propelled and sea-going, regardless of classification. Before the time, only those vessels classed by Lloyd's Register were listed. Vessels are listed alphabetically by their current name.
