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Methods in Cancer Immunity and Immunotherapy: 2022
This Research Topic is part of the “Methods in Immunology” series. Please submit your article to the Research Topic that best suits the focus of your research. Introduction and general guidelines: This series aims to highlight the latest experimental techniques and methods used to investigate fundamental questions in Immunology research, with a focus on Cancer Immunity and Immunotherapy.
Nanostructured Magnetic Materials
Functionalized magnetic nanomaterials are used in data storage, biomedical, environmental, and heterogeneous catalysis applications but there remain developmental challenges to overcome. Nanostructured Magnetic Materials: Functionalization and Diverse Applications covers different synthesis methods for magnetic nanomaterials and their functionalization strategies and highlights recent progress, opportunities, and challenges to utilizing these materials in real-time applications. Reviews recent progress made in the surface functionalization of magnetic nanoparticles Discusses physico-chemical characterization and synthesis techniques Presents the effect of the external magnetic field Details biological, energy, and environmental applications as well as future directions This reference will appeal to researchers, professionals, and advanced students in materials science and engineering and related fields.
New Frontiers in Gene-Modified T Cell Technology
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
