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Imaging in Acute Stroke – New Options and State of the Art
One in six suffers a stroke during their lifetime and stroke remains the major cause of new onset disability in adulthood. The worldwide burden of stroke is increasing due to an ageing population, however, globally haft of stroke victims are young. Stroke is the clinical diagnosis of an acute vascular incident and covers a multitude of pathophysiological causes. The clinician needs imaging to make decisions on acute treatment as well as to plan a secondary prevention strategy: a non-contrast CT and a Duplex of the carotids followed by an aspirin as a one size fits all strategy does not always provide sufficient support for those decisions. Presently, fast, generally available, and non-invasi...
Stroke Medicine
This collection of case studies is authored by a group of internationally recognised experts in the field of cerebrovascular disease. The cases are carefully selected to provide an insight into the different kinds of stroke syndromes from the common through to more rare presentations of cerebrovascular pathology. Each case is worked through with a discussion on presentation, clinical features, examination, radiological findings and management. Finally, learning points are highlighted to help the reader focus on the key points of the case study. Stroke Medicine: Case Studies from Queen Square is aimed at medical students and doctors in all stages of training from foundation years through to consultancy.
Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy
Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects. We investigated clinical (neuroimaging and cognitive) biomarkers in the SVD, through a series of analyses from our five studies. Sporadic cerebral SVD is a complex 'micro-world' to be globally considered. All the relevant lesion types and SVD neuroimaging burden should be taken into account. The cumulative effects of microangiopathy burden in the brain of patients affected by SVD are crucial. Cognitive rehabilitation could represent a promising approach to prevent vascular dementia or to improve cognitive performances in patients with cerebral SVD. Longitudinal studies may provide more robust information about the progression and prognostic significance of our findings.
History of Stroke
Stroke is one of the leading causes of disability and death worldwide. It has become the first disease leading to neurologic referrals to hospital and, while recognized in medicine since antiquity, stroke did not acquire a proper place within neurology until the second part of the 20th century. The main reason for this is that, because it deals with blood vessels and circulation, neurologists themselves did not want to include stroke as a primary disorder of the nervous system. However, this is one of the many reasons the historical development of stroke and cerebrovascular disease is of unique interest; it touches not only on neurology but also on internal medicine, angiology, cardiology, r...
Principles Underlying Post-Stroke Recovery of Upper Extremity Sensorimotor Function – A Neuroimaging Perspective
Neuroimaging post-stroke has the potential to uncover underlying principles of disordered function and recovery characterizing defined patient groups, including their long term course as well as individual variations. (MRI) measuring task related activation as well as resting state. Functional MRI can be performed by MRI to detect blood flow and associated changes in brain function. For structural MRI robust and accurate computational anatomical methods like voxel-based morphometry and surface based techniques are available. The investigation of the connectivity between brain regions and disruption after stroke is facilitated by diffusion tensor imaging (DTI). Intra- and interhemispheric coh...
Bradley's Neurology in Clinical Practice E-Book
A practical, dynamic resource for practicing neurologists, clinicians and trainees, Bradley and Daroff's Neurology in Clinical Practice, Eighth Edition, offers a straightforward style, evidence-based information, and robust interactive content supplemented by treatment algorithms and images to keep you up to date with all that's current in this fast-changing field. This two-volume set is ideal for daily reference, featuring a unique organization by presenting symptom/sign and by specific disease entities—allowing you to access content in ways that mirror how you practice. More than 150 expert contributors, led by Drs. Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy, and Nancy J. Newma...
Cerebral Microbleeds
Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.
Frontiers in Clinical Drug Research - Alzheimer Disorders
Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer's disease (AD), a disease that causes dementia, or loss of brain function. This disease affects parts of the brain that affect memory, thought and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews writ...
