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Skin Autoimmunity
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Autoantibodies
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Cow's Milk and Allergy
The purpose of this Special Issue “Cow’s Milk and Allergy” is to provide an overview of the association of cow’s milk with allergy. This topic has two quite different faces. On the one hand, we are all aware of the importance of cow’s milk allergy in early life. What is less known is that the consumption of raw, unprocessed milk is associated with a lower incidence of asthma and rhinitis. This Special Issue takes a closer look at all of these aspects of cow’s milk and allergy and focus on the following questions: -Mechanisms of cow’s milk allergy -Epidemiology of cow’s milk allergy -Prevention of cow’s milk allergy -Management and immunotherapy of cow’s milk allergy -Milk processing, baked milk, and cow’s milk allergy -The consumption of raw milk and inhalation allergies
Pruritus Medicine
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Pemphigus and pemphigoid diseases: in memoriam Detlef Zillikens
Pemphigus and pemphigoid diseases are a heterogenous group of autoimmune blistering disorders (AIBD) characterized by tissue-bound and circulating autoantibodies against structural proteins of the desmosome and basement membrane zone of the skin and orifice-close mucosal tissues. While strong evidence has been provided that autoantibodies in AIBD are pathogenic, the exact mechanisms of how blister formation is mediated is very different between pemphigus and pemphigoid disorders and yet incompletely understood. Additionally, target antigens for the major AIBDs have already been identified on the molecular level. In contrast, diagnostic assays are not yet available for all autoantibody specif...
Inflammation in Skin-Related Diseases
It has been revealed that inflammation plays an important role in the progression of skin-related diseases, including burn or trauma wounds, diabetes wounds, pressure ulcers, radiation ulcers, keloids, hypertrophic scars, dermatitis, eczema, psoriasis, vitiligo, etc, causing skin tissue to exhibit over-inflammation, lower inflammation, or chronic inflammation. During this process, bacteria invasion, microbiota dysbiosis, or autoimmunity are known as the general initiators to induce the abnormal activity of immune cells and molecules and could change the crosstalk between immune cells and repair cells (or interstitial cells). Therefore, the research deep into the novel mechanisms of inflammation, the new signal pathway of immunity chain responses, or the new relationship between inflammation and repair cells, is of great interest for the design of novel therapies for skin-related diseases.
New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Artificial Intelligence in Cutaneous Lesions: Where do we Stand and What is Next?
There has been a growing amount of research detailing the use of Artificial Intelligence (AI) in cutaneous diseases. Nonetheless, we still do not have a regulatory agency approved app or computer system being used by dermatologists (or other physicians that could be confronted with challenging skin lesions) in daily practice. Why is this? Where do we stand now? What is next in this field? It is time to deeply explore this theme.
