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Modeling and Parameter Estimation for Heterogeneous Cell Populations
Most of the modeling performed in biology aims at achieving a quantitative description and understanding of the intracellular signaling pathways within a "typical cell". However, in many biologically important situations even genetically identical cell populations show a heterogeneous response. This means that individual members of the cell population behave differently. Such situations require the study of cell-to-cell variability and the development of models for heterogeneous cell populations. The main contribution of this thesis is the development of unifying modeling frameworks for signal transduction and proliferation processes in heterogeneous cell populations. These modeling framewor...
Deception
________________________________ 'Putin [and] his friends ... are gangsters on a scale that makes Al Capone or the Corleones seem small-time ... Lucas is right to castigate our folly in treating all this so lightly.' - Max Hastings, Sunday Times 'This important book is a sequel to the author's last indictment of the Putin regime, The New Cold War, which came out four years ago. Deception is, if anything, even more devastating.' - Standpoint 'Urgent and heartfelt.' - The Times _____________________________________ From the capture of Sidney Reilly, the 'Ace of Spies', by Lenin's Bolsheviks in 1925, to the deportation from the USA of Anna Chapman, the 'Redhead under the Bed', in 2010, Kremlin ...
The Gun
The AK-47, or 'Kalashnikov', is the most abundant and efficient firearm on earth. It is so light it can be used by children. It has transformed the way we fight wars, and its story is the chilling story of modern warfare. C. J. Chivers's extraordinary new book tells an alternative history of the world as seen through these terrible weapons. He traces them back to their origins in the early experiments of Gatling and Maxim, and examines the first appearance of the machine-gun. The quest for ever greater firepower and mobility culminated in the AK-47 at the beginning of the Cold War, a weapon so remarkable that, over sixty years after its invention and having broken free of all state control, it has become central to civil wars all over the world.
The Limits of Partnership
A gripping account of U.S.-Russian relations since the end of the Soviet Union The Limits of Partnership is a riveting narrative about U.S.-Russian relations from the Soviet collapse through the Ukraine crisis and the difficult challenges ahead. It reflects the unique perspective of an insider who is also recognized as a leading expert on this troubled relationship. American presidents have repeatedly attempted to forge a strong and productive partnership only to be held hostage to the deep mistrust born of the Cold War. For the United States, Russia remains a priority because of its nuclear weapons arsenal, its strategic location bordering Europe and Asia, and its ability to support—or th...
European Security in the Twenty-First Century
Combining a sophisticated theoretical analysis with detailed empirical case-studies, this book provides an original view of the challenges and threats to a stable peace order in Europe. The end of Cold War bipolarity has transformed Europe. Using structural realist theory, Adrian Hyde-Price analyzes the new security agenda confronting Europe in the twenty-first century. Europe, he argues, is not ‘primed for peace’ as mainstream thinking suggests, rather, it faces new security threats and the challenge of multipolarity. This critical and original volume looks at European security after the Iraq War, the failure of the EU constitution and the change of government in Germany. Reflecting on the inherently competitive and tragic nature of international politics, it concludes that realism provides the only firm foundations for an ethical foreign and security policy. European Security in the Twenty-First Century will appeal to students and scholars of international relations, European politics and security studies.
Russia--lost in Transition
Russian history is first and foremost a history of personalized power. As Russia startles the international community with its assertiveness and faces both parliamentary and presidential elections, Lilia Shevtsova searches the histories of the Yeltsin and Putin regimes. She explores within them conventional truths and myths about Russia, paradoxes of Russian political development, and Russia's role in the world. Russia--Lost in Transition discovers a logic of government in Russia--a political regime and the type of capitalism that were formulated during the Yeltsin and Putin presidencies and will continue to dominate Russia's trajectory in the near term. Looking forward as well as back, Shevtsova speculates about the upcoming elections as well as the self-perpetuating system in place--the legacies of Yeltsin and Putin--and how it will dictate the immediate political future. She also explores several scenarios for Russia's future over the next decade.
Synchronization of Oscillators and Global Output Regulation for Rigid Body Systems
The investigation of nonlinear dynamis in physical and engineering systems from the point of view of systems and control theory is important to develop better engineering systems. Synchronization of oscillators and output regulation for rigid body systems are two problem classes which are inherently nonlinear and are of great importance in applications. This thesis contains novel results for both problem classes. In the case of sychronization of oscillators we consider two different system classes and give sufficient or necessary conditions for synchronization. In the case of the output regulation problems for rigid body systems we provide a new two-step control design procedure, a detailed analysis for the error dynamics and an application scenario for satellite control. A highlight of the thesis is a new separation principle which is the underlying principle of the two-step design procedure for the output regulation problem.
Putin's ʻpreventive Counter-revolutionʼ
This text examines the preventive counter-revolution undertaken by the Putin leadership in response to political instability - the colour revolutions - in the former post-Soviet republics and their potential to destabilise Russia itself.
Beijing's Power and China's Borders
China shares borders with 20 other countries. Each of these neighbors has its own national interests, and in some cases, these include territorial and maritime jurisdictional claims in places that China also claims. Most of these 20 countries have had a history of border conflicts with China; some of them never amicably settled. This book brings together some of the foremost historians, geographers, political scientists, and legal scholars on modern Asia to examine each of China's twenty land or sea borders.
WHEEL OF FORTUNE
The world’s largest exporter of oil is facing mounting problems that could send shock waves through every major economy. Gustafson provides an authoritative account of the Russian oil industry from the last years of communism to its uncertain future. The stakes extend beyond global energy security to include the threat of a destabilized Russia.
