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Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.
Considers the evidence for the existence of unifying rules controlling the formation and maintenance of ecological communities.
This volume presents an overview of current accomplishments and future directions in ecological theory. The twenty-three chapters cover a broad range of important topics, from the physiology and behavior of individuals or groups of organisms, through population dynamics and community structure, to the ecology of ecosystems and the geochemical cycles of the entire biosphere. The authors focus on ways in which theory, whether expressed mathematically or verbally, can contribute to defining and solving fundamental problems in ecology. A second aim is to highlight areas where dialogue between theorists and empiricists is likely to be especially rewarding. The authors are R. M. Anderson, C. W. Cl...
In this book, plant biology is considered from the perspective of plants and their surrounding environment, including both biotic and abiotic interactions. The intended audience is undergraduate students in the middle or final phases of their programs of study. Topics are developed to provide a rudimentary understanding of how plant-environment interactions span multiple spatiotemporal scales, and how this rudimentary knowledge can be applied to understand the causes of ecosystem vulnerabilities in the face of global climate change and expansion of natural resource use by human societies. In all chapters connections are made from smaller to larger scales of ecological organization, providing...
A summary of state-of-the-art research on how the river environment impacts biodiversity, species invasions, population dynamics, and the spread of waterborne disease. Blending laboratory, field and theoretical studies, it is the go-to reference for graduate students and researchers in river ecology, hydrology, and epidemiology.
Abiotic stresses such as drought (water deficit), extreme temperatures (cold, frost and heat), salinity (sodicity) and mineral (metal and metalloid) toxicity limit productivity of crop plants worldwide and are big threats to global food security. With worsening climate change scenarios, these stresses will further increase in intensity and frequency. Improving tolerance to abiotic stresses, therefore, has become a major objective in crop breeding programs. A lot of research has been conducted on the regulatory mechanisms, signaling pathways governing these abiotic stresses, and cross talk among them in various model and non-model species. Also, various ‘omics’ platforms have been utilize...
This pocket book offers a succinct but comprehensive overview of the role of PET/CT in radiotherapy planning. Individual chapters are devoted to specific application of the technique to particular tumor types, including non-small cell lung, gastrointestinal, head and neck squamous cell, prostate, gynecological, and pediatric tumors. Helpful information is also presented on the practical implementation of PET/CT in routine oncological practice. Technical and logistical issues are discussed, and guidance provided on potential problems and pitfalls and available solutions. The book will be invaluable in assisting readers to exploit PET/CT’s ability to significantly improve delineation of tumor tissue through the addition of metabolic information to structural imaging data, thereby avoiding unnecessary radiation injury and associated complications while enhancing therapeutic effects and minimizing the risk of marginal recurrences. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, compiled under the auspices of the British Nuclear Medicine Society.
A major literary figure and frequent contributor to the Yiddish-language newspaper Forverts from the 1920s to the mid-1930s, Jonah Rosenfeld was recognized during and after his lifetime as an explorer of human psychology. His work foregrounds loneliness, social anxiety, and people’s frustrated longing for meaningful relationships—themes just as relevant to today’s Western society as they were during his era. The Rivals and Other Stories introduces nineteen of Rosenfeld’s short stories to an English-reading audience for the first time. Unlike much of Yiddish literature that offers a sentimentalized view of the tight knit communities of early twentieth-century Jewish life, Rosenfeld’...