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Glutathione System and Oxidative Stress in Health and Disease
The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Information Technology for Counterterrorism
Information technology (IT) is essential to virtually all of the nation's critical infrastructures making them vulnerable by a terrorist attack on their IT system. An attack could be on the system itself or use the IT system to launch or exacerbate another type of attack. IT can also be used as a counterterrorism tool. The report concludes that the most devastating consequences of a terrorist attack would occur if it were on or used IT as part of a broader attack. The report presents two recommendations on what can be done in the short term to protect the nation's communications and information systems and several recommendations about what can be done over the longer term. The report also notes the importance of considering how an IT system will be deployed to maximize protection against and usefulness in responding to attacks.
Playbooks and their Readers in Early Modern England
This book is the first comprehensive examination of commercial drama as a reading genre in early modern England. Taking as its focus pre-Restoration printed drama’s most common format, the single-play quarto playbook, it interrogates what the form and content of these playbooks can tell us about who their earliest readers were, why they might have wanted to read contemporary commercial drama, and how they responded to the printed versions of plays that had initially been performed in the playhouses of early modern London. Focusing on professional plays printed in quarto between 1584 and 1660, the book juxtaposes the implications of material and paratextual evidence with analysis of historical traces of playreading in extant playbooks and manuscript commonplace books. In doing so, it presents more detailed and nuanced conclusions than have previously been enabled by studies focused on works by one author or on a single type of evidence.
