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Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier
Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.
Modern Regulations and Practices for Social and Environmental Accounting
There has been an increased interest in social and environmental issues in recent years as more consideration is given to the idea of sustainability and social accounting. Social accounting can be considered a straightforward manifestation of corporate enforcement to legitimize, explain, and justify the organization’s activities or an ethically desirable component of any well-functioning democracy. Social accounting can also include environmental accounting, which is focused on environmental issues. Additional study is required to better understand the relevancy of social and environmental accounting in today’s modern business world. Modern Regulations and Practices for Social and Environmental Accounting discusses social and environmental accounting and considers regulations, norms, organizational practices, and the challenges of education. Covering a range of topics such as non-financial reporting and corporate social responsibility, this reference work is ideal for industry professionals, researchers, academicians, managers, practitioners, instructors, and students.
Estudos sobre línguas e literaturas na educação básica
Esta obra é resultado de pesquisas envolvendo diferentes perspectivas para o ensino de línguas e literaturas na Educação Básica. Conta com textos oriundos de distintas regiões brasileiras e de diferentes realidades. É um produto que pode ser consultado por estudantes de licenciaturas e por professores que já atuam, pois encontrarão propostas de ensino bastante atuais.
Immunobiology of Leishmaniasis
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Epitope Discovery and Synthetic Vaccine Design
Since variolation, conventional approaches to vaccine development are based on live-attenuated, inactivated or purified pathogen-derived components. However, effective vaccines against global health threats such as HIV, parasite infections and tumors are difficult to achieve. On the other hand, synthetic vaccines based on immunogenic epitopes offer advantages over traditional vaccines since they are chemically defined antigens free from deleterious effects. Additionally, in contrast to live-attenuated vaccines, they do not revert to virulence in immunocompromised subjects, and different from genetic vaccines, they do not involve ethical questions. Traditional vaccines contain PAMPs and induc...
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Coronavírus e responsabilidade civil
"Como se vê do abrangente temário da obra, o IBERC e os autores dos 44 artigos que a compõem pretendem fornecer instrumento útil de reflexão científica, em meio aos primeiros impactos da pandemia no ambiente jurídico-normativo. Trata-se de livro que busca projetar luzes sobre problemas da responsabilidade civil que se inserem com absoluta prioridade na pauta das preocupações de advogados, juízes, professores e estudantes. De fato, diante dos gigantescos desafios que se avizinham, a difusão e o aprimoramento constante do conhecimento técnico-científico tornam-se método seguro e permanente para lidar com as incertezas do porvir e, sob tais circunstâncias, a doutrina, mais do que...
Coronavírus e responsabilidade civil
A parte introdutória desta obra coletiva fica a cargo da Professora da Faculdade de Direito de Coimbra, Mafalda Miranda Barbosa, com o artigo versando sobre "Coronavírus: a responsabilidade na experiência europeia – o caso Português". A autora principia em uma bipartição quanto às projeções negativa e positiva ao nível da responsabilidade civil. No aspecto negativo a covid-19 pode conduzir a uma exclusão da responsabilidade contratual, seja diante da força maior (impossibilidade de cumprimento não imputável ao devedor) ou nas situações em que, não havendo impossibilidade, o instituto da alteração superveniente das circunstâncias torna-se operante. Positivamente, a covid...
