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Multisystem Inflammatory Syndrome in Children
Since April 2020, pediatric patients in Europe and the USA were reported presenting Kawasaki Disease-like shock syndrome. These patients showed pictures of variable severity up to multiorgan involvement and hyper inflammation, sometimes requiring intensive care. The CDC later defined this condition as Multisystem Inflammatory Syndrome in Children (MIS-C). The following diagnostic criteria were established: age <21 years; fever >24 hours; blood chemistry tests compatible with an inflammatory state; involvement of at least 2 organs or systems; severe clinical conditions requiring hospitalization; exclusion of other possible diagnoses, recent exposure (>4 weeks) to SARS-CoV-2 or positive nasopharyngeal swab or previous infection ascertained on serological examination. The immunopathogenesis of MIS-C is unclear but overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology has been described.
Why We Buy
Guide to ever-evolving consumer culture, offering advice on how to keep current customers and attract new ones.
New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Worldwide Government Directory with Intergovernmental Organizations 2013
Published for more than 24 years, there is no substitute for the Worldwide Government Directory, which allows users to identify and reach 32,000 elected and appointed officials in 201 countries, plus the European Union. Extensive coverage that includes over 1,800 pages of executive, legislative and political branches; heads of state, ministers, deputies, secretaries and spokespersons as well as state agencies, diplomats and senior level defense officials. It also covers the leadership of more than 100 international organizations. World Government contact information that includes phone numbers and email. Listings include: Name, addresses, telephone and fax numbers, email and web addresses Titles Hierarchical arrangements defining state structures
Intelligent Transport Systems In Europe: Opportunities For Future Research
This book provides valuable insight and critical appraisal of key areas of intelligent transport systems (ITS) for land transport in Europe. ITS is becoming increasingly important as the means to improving the efficiency, safety and comfort of the transport of people and goods while at the same time helping to minimize environmental damage and the contribution of transport to global warming.The material draws on over four years of study by the ROSETTA project — part of the European Commission 5th Framework Program. For each of the 12 areas addressed, the book provides a vision for their application, identifies key issues yet to be addressed and the future opportunities that the timely application and advancement of ITS can bring.
