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Anion Carriers of Mitochondrial Membranes
In order to provide a functional organisation of the various biochemical processes, the intracellular environment is subdivided into compartments formed by organelles. Mitochondria serve to restore energy-rich compounds, while energy is mainly consumed in the cytosolic space. Molecules involved in these metabolic cycles have to cross the mitochondrial membrane via specialized carriers embedded in the inner mitochondrial membrane. All relevant structural and functional aspects of the Anion Carriers of Mitochondrial Membranes as well as isolation procedures, reconstitution experiments and biogenesis of the carriers, kinetics of transport as well as the metabolic regulation mechanisms are treated in this volume.
Membrane Proteins
This volume is the third of a series on Membrane Proteins and, like the pre ceding manuals, is the result of an International Advanced Course entitled Isolation and Characterization of Membrane Proteins: Biochemical and Bio physical Aspects sponsored by the Federation of European Biochemical So cieties (FEBS) and the Italian Research Council (CNR). The success of the course and the continuous development in the field of membrane biology has prompted me to publish also in this case the protocols of the experiments which were carried out by the students. The students have been able not only to perform the experiments pub lished in this manual without help from the instructors, but also to sugg...
New Topics in Vitamin E Research
The term vitamin E describes a family of eight antioxidants, four tocopherols, alpha-, beta-, gamma- and delta-, and four tocotrienols (also alpha-, beta-, gamma- and delta-). Alpha-tocopherol is the only form of vitamin E that is actively maintained in the human body and is therefore, the form of vitamin E found in the largest quantities in the blood and tissue (1). Alpha-tocopherol is the form of vitamin E that appears to have the greatest nutritional significance. This volume presents leading-edge research in this important field.
Antioxidants in Diabetes Management
This volume summarizes current understanding of the pathogenic role of oxidative stress in the onset and progression of diabetes and its complications, and presents results of studies aimed at regulating oxidatively induced complications through the use of antioxidants. Examines the presence of impaired microcirculation, capillary hypoxia, and ischemia syndrome in diabetic complications! Designed to stimulate scientific discussion and curiosity about the causes of diabetes, with contributions from nearly 65 clinicians and researchers who cite more than 1300 sources, Antioxidants in Diabetes Management focuses on stringent control of hyperglycemia to prevent or modify onset and progression pr...
Membranes and Transport
This work is a collection of short reviews on membranes and transport. It portrays the field as a mosaic of bright little pieces, which are interesting in themselves but gain full signif icance when viewed as a whole. Traditional boundaries are set aside and biochemists, biophysicists, physiologists, and cell biologists enter into a natural discourse. The principal motivation of this work was to ease the problems of communication that arose from the explosive growth and interdisciplinary character of membrane research. In these volumes we hope to provide a readily available comprehensive source of critical information covering many of the exciting, recent developments on the structure, biosy...
Molecular Aspects of Cancer and its Therapy
On the basis of the agreement signed between UNESCO and the Government of the Republic of Poland the International Institute for Cell and Molecular Biology of UNESCO was officially inaugurated in October 1995 in Warsaw, Poland, as part of the activity of the Global Network for Molecular and Cell Biology (MCBN) of UNESCO. The occasion was marked by the bringing together in Warsaw of a broad spectrum of cell and molecular biologists from around the world under the auspices of the Global MCBN UNESCO. At the conclusion of that week-long celebration it became clear that Polish cell and molecular biology had come of age in terms of its depth, vigor and impact on the global scene. At the suggestion...
Molecular Basis of Neurological Disorders and Their Treatment
cytochemical techniques (ICC) which provide a useful adjunct to investigations by immunoblotting. A particular advantage of a cytochemical approach to the investiga tion of mitochondrial disorders is that it allows the mosaic distribution of certain of these defects to be detected, whereas the tissue homogeniza tion involved in conventional enzyme assays or immunoblotting precludes this. A further advantage of MEA or ICC is that only small amounts of tissue are needed, which is important since many of the affected patients are infants or small children. The main aim of this communica tion is to outline ways in which these techniques can be used in the diagnosis and further investigation of m...
Critical Reviews of Oxidative Stress and Aging
This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.
