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A Prospective Non-interventional Study on the Impact of Transfusion Burden and Related Iron Toxicity on Outcome in Myelodysplastic Syndromes Undergoing Allogeneic Hematopoietic Cell Transplantation
Abstract: Most myelodysplastic syndromes (MDS)-patients receive multiple red blood cell transfusions (RBCT). Transfusions may cause iron-related toxicity and mortality, influencing outcome after allogeneic HSCT. This prospective non-interventional study evaluated 222 MDS and CMML patients undergoing HSCT. Overall survival (OS), relapse-free survival (RFS), non-relapse mortality (NRM), and relapse incidence (RI) at 36 months were 52%, 44%, 25%, and 31%, respectively. Age, percentage of marrow blasts and severe comorbidities impacted OS. RFS was significantly associated with RBCT burden prior to HSCT (HR: 1.7; p = .02). High ferritin levels had a significant negative impact on OS and RI, but n...
Innovations in Stem Cell Transplantation
This book documents the increased number of stem cell related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world. It thereby complements and extends the basic coverage of stem cells such as immunogenetics, neuron replacement therapy, cover hematopoietic stem cells, issues related to clinical problems, advanced HLA typing, alternative donor sources as well as gene therapy that employs novel methods in this field. Clearly, the treatment of various malignancies and biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.
Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion
Abstract: The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS. An increased number of blasts and additional karyotypic abnormalities (del [5q]+) are associated with a poor outcome. We analyzed the outcome of allogeneic hematopoietic cell transplants (HCT) in patients suffering from MDS with only del (5q) or del (5q)+ . A total of 162 patients, of median age 54 years (range, 9 to 73), having MDS and del (5q) abnormalities received HCT from identical siblings (n = 87) or unrelated donors (n = 75). The cumulative incidence of nonrelapse mortality and relapse incidence at 4 years was 29% (95% CI, 22 to 36) and 46% (95% CI, 38 to 54), whereas the estimated 4 year survival, relapse-free and overall, was 25% (95% CI, 18 to 33) and 30% (95% CI, 23 to 38), respectively. In a multivariate analysis patients with del (5q) and a blast excess displayed poorer survival (hazard ratio, 2.38; 95% CI, 1.44 to 3.93; P
Candidates, Parties and Voters in the Belgian Partitocracy
This book focuses on the triadic relationship between electoral candidates and the two other poles of the delegation and accountability triangle—political parties and voters. The chapters rely mostly on the Belgian Candidate Survey (CCS project), gathering about 2000 candidates belonging to 15 parties represented in Parliament and running for the 2014 federal and regional elections, and the authors’ conclusions serve at answering broad political science questions linked with elite recruitment, party and candidate electoral strategies, personalisation, party cohesion, and descriptive and substantive representation. Its multilevel semi-open electoral system, atypical federal structure, extreme party system fragmentation and volatility make Belgium an exceptionally rich but complex case that offers findings highly relevant to research on candidates in other democracies.
The EBMT Handbook
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
The EBMT/EHA CAR-T Cell Handbook
This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.
European Politics
European Politics expertly and accessibly surveys the history, institutions, and issues that are essential for understanding contemporary European politics. Exploring a central question—"what is Europe?"—this text's thematic approach helps students compare politics in individual countries and see the political big picture in the region. European Politics examines not only countries which are (or were) in the European Union but also those eligible to join, to give students the most comprehensive picture of Europe's evolution in a globalized world. Key changes for the new edition include: coverage of hot topics such as Brexit, Covid-19, rise of nationalist-populists, authoritarian developm...
Om nooit te vergeten
Om nooit te vergeten is een bundel korte verhalen van Nederlands talent Thomas Olde Heuvelt, die eerder internationaal doorbrak met HEX. Stephen King noemde zijn werk ‘briljant en volstrekt origineel’ Om nooit te vergeten is een bundel korte verhalen van Nederlands talent Thomas Olde Heuvelt, die eerder internationaal doorbrak met HEX. Stephen King noemde zijn werk ‘briljant en volstrekt origineel’. Voor het eerst zijn nu vijf van zijn verhalen gebundeld. Twee ervan werden nooit eerder gepubliceerd. De verhalen delen thema’s over leven en dood, verlies of liefde. De meeste spelen zich af op het grensgebied van het magisch-realistische. Sommige verhalen zijn schitterend, andere griezelig en volstrekt onweerstaanbaar. Maar allemaal zijn het verhalen om nooit te vergeten.
