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Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury
Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barri...
Handbook of translational medicine
This handbook aims to capture the basic concepts of translational medicine, understood as a branch of the biomedical field that translates discoveries into the clinical setting. This discipline is currently closing the gap between basic science and clinical research. The book is intended to be straightforward, easy-to-read, intelligible and practical. It describes the basic principles of translational medicine, including major advances in genomics, new technologies, the processing of big data and biobanks. Regarding the biological foundations of translational medicine, we address concepts related to the molecular basis of cancer, inflammation, angiogenesis, stem cells and experimental models...
Activating Youth as Change Agents
In Activating Youth as Change Agents, editors Amy L. Cook and Ian P. Levy describe the applications of Youth Participatory Action Research (YPAR) as a youth-oriented group process where school counselors collaborate alongside students in developmentally relevant ways to achieve their goals toward personal growth and positive school-community improvement. The book provides practitioners and counselors-in-training with group-counseling skills focused on action and how to engage in social justice efforts both locally at their school and in their communities.
Youth Dialogues on Race and Ethnicity
In Youth Dialogues on Race and Ethnicity, Barry Checkoway describes the work of a specific university-community partnership program: Youth Dialogues on Race and Ethnicity in Metropolitan Detroit. Including an analysis of the program's origins and objectives, activities and accomplishments, facilitating and limiting factors, and lessons learned from practice, Checkoway provides an unprecedented example of young people working together across segregated boundaries to transform their lives and communities. He also examines youth dialogues as a process, young people as change agents, adults as allies and partners, and the anchor institutions that support this work.
Cities & Rivers
A selection of architecture, landscape and urbanism works from aldayjover | architecture and landscape, an office based in Barcelona, Spain and Virginia in the United States. A collection of projects -- designed from their local and territorial DNA -- that respond in new ways to the global socio-ecological crisis in which we have been in engaged with since the beginning of the 21st century. Featured works include public spaces, architecture and urban studies that incorporate natural dynamics and that also emphasize -- recovering in some cases -- legal access among all citizens and equal access to the city and its opportunities. The works presented are particularly renowned given their leadership role in a new approach to the relationship between cities and rivers, in which natural dynamics become part of the public space, eliminating the effect of “catastrophe”.
A Holter for Parkinson’s Disease Motor Symptoms: STAT-OnTM
A new information and communication technology (ICT) has been deployed in the battle against Parkinson’s disease, a neurodegenerative disorder that is both progressive and disabling with significant impact on quality of life. This book explains the experience following from the achieved results in the REMPARK project on Parkinson’s disease management up to the launch of a new medical product to the European market, STAT-ONTM. The new medical device, STAT-ONTM is a real Holter for the motor symptoms associated to PD. It provides objective information about the severity and distribution of PD motor symptoms and their fluctuations in daily life, allowing for an unbiased and correct monitori...
Changing Landscapes for Childhood and Youth in Europe
Contemporary social transformations, characterised by multi-dimensional globalisation and technological change, have lent new impetus to the emergence of internationally oriented and interdisciplinary childhood and youth studies. Analysis of sharpened polarisations of chances and risks within and between generations in specific life circumstances meets up with the re-conceptualisation of childhood and youth as social constructions within the life-course. As such, insulated national discourses are no longer an adequate framework to address such issues: economic and cultural globalisation processes exert dual and reciprocal influences, restructuring societies and identities from within and wit...
Urban Futures
Given the rapid evolution of concepts such as smart cities, who are the architects riding the wave of new possibilities for urban design? How do contemporary agencies find pathways to understand the challenges and opportunities presented by evolving urban technology, and how does architecture engage with the expanding pool of associated disciplines? How should schools of architecture and urban design engage with radical digitalised urbanism? This issue of AD claims that this is contested territory. The two-dimensionality of planners’ urban construct is as limited as engineers’ predilection to zero-in and solve problems. Urban Futures contends that society needs a much broader professiona...
Al lado de
The unresolved limits of the post-capitalist city give rise to interventions in the city and the contemporary landscape in which the planner has to rely on a knowledge of other fields. The inevitable multidisciplinary activity at these frontiers has been an object of study during recent decades. This book brings together these reflections and some of their achievements in projects whose common denominator is their condition of marginality, of contiguity with prior structures with which they try to establish connections and continuities. The four parts into which the book is divided make reference to projectural policies conditioned by work on the boundaries of the pre-existing and to the interpretation of their settings: stretches of water, infrastructures, cultural and artificial natures. Analysed here are border zones, edges, frontiers and fringes of the contemporary city with itself, with nature, and with the boundaries between the natural and the colonised landscape.
