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Dynamic Force Spectroscopy and Biomolecular Recognition
Molecular recognition, also known as biorecognition, is the heart of all biological interactions. Originating from protein stretching experiments, dynamic force spectroscopy (DFS) allows for the extraction of detailed information on the unbinding process of biomolecular complexes. It is becoming progressively more important in biochemical studies a
Functional Domain Motions and Processivity in Bacterial Hyaluronate Lyase
Processive enzymes are a special class of enzymes which presumably remain attached to their polymeric substrates between multiple rounds of catalysis. Due to this property, the substrate slides along the enzyme and reduces the time for the random diffusional enzyme-substrate encounters thereby increasing the efficiency of these enzymes manifold. Although structural information from many processive enzymes is available, the atomistic details of particularly the substrate sliding process, which is an inherently dynamic process, remain largely unknown. We take first steps to understand the sliding process by investigating a prototypic processive enzyme: Streptococcus Pneumoniae Hyaluronate lyas...
Surface-Enhanced Raman Scattering
Almost 30 years after the first reports on surface-enhanced Raman signals, the phenomenon of surface-enhanced Raman scattering (SERS) is now well established. SERS gained particular interest after single-molecule Raman spectroscopy had been demonstrated. This book summarizes and discusses present theoretical approaches that explain the phenomenon of SERS and reports on new and exciting experiments and applications of the fascinating spectroscopic effect.
Physical Review
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Politics of Culture in Liberal Italy
Exploring theatre and opera, architecture and urban planning, the medieval revival and the rediscovery of the Etruscan and Roman past, this book analyzes Italians' changing relationship to their new nation state and the monarchy, class conflicts, and the emergence of new belief systems and of scientific responses to the experience of modernity.
Isis Pelagia: Images, Names and Cults of a Goddess of the Seas
In Isis Pelagia: Images, Names and Cults of a Goddess of the Seas, Laurent Bricault, one of the principal scholars of the cults of Isis, presents a new interpretation of the multiple sources that present Isis as a goddess of the seas. Bricault discusses a wealth of relatively unknown archaeological and textual data, drawing on a profound knowledge of their historical context. After decades of scholarly study, Bricault offers an important contribution and a new phase in the debate on understanding the “diffusion” as well as the “reception” of the cults of Isis in the Graeco-Roman world. This book, the first English-language monograph by the leading French scholar in the field, underlines the importance of Isis Studies for broader debates in the study of ancient religion.
Functionally Relevant Macromolecular Interactions of Disordered Proteins
Disordered proteins are relatively recent newcomers in protein science. They were first described in detail by Wright and Dyson, in their J. Mol. Biol. paper in 1999. First, it was generally thought for more than a decade that disordered proteins or disordered parts of proteins have different amino acid compositions than folded proteins, and various prediction methods were developed based on this principle. These methods were suitable for distinguishing between the disordered (unstructured) and structured proteins known at that time. In addition, they could predict the site where a folded protein binds to the disordered part of a protein, shaping the latter into a well-defined 3D structure. ...
Dynamic Force Spectroscopy and Biomolecular Recognition
Molecular recognition, also known as biorecognition, is the heart of all biological interactions. Originating from protein stretching experiments, dynamic force spectroscopy (DFS) allows for the extraction of detailed information on the unbinding process of biomolecular complexes. It is becoming progressively more important in biochemical studies and is finding wider applications in areas such as biophysics and polymer science. In six chapters, Dynamic Force Spectroscopy and Biomolecular Recognition covers the most recent ideas and advances in the field of DFS applied to biorecognition: Chapter 1: Reviews the basic and novel aspects of biorecognition and discusses the emerging capabilities o...
